77476-95-0

Basic information

• Product Name: 5-BROMO-2-(ISOPROPYLAMINO)PYRIMIDINE
• Synonyms: 5-BROMO-2-(ISOPROPYLAMINO)PYRIMIDINE;2-PYRIMIDINAMINE, 5-BROMO-N-(1-METHYLETHYL)-;(5-Bromopyrimidin-2-yl)isopropylamine;5-Bromo-N-isopropylpyrimidin-2-amine;5-Bromo-N-(prop-2-yl)pyrimidin-2-amine, 5-Bromo-2-(isopropylamino)-1,3-diazine
• CAS NO: 77476-95-0
• Molecular Formula: C7H10BrN3
• Molecular Weight: 216.08
• Mol File: 77476-95-0.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 289.5 °C at 760 mmHg
• Flash Point: 128.9 °C
• Appearance: /
• Density: 1.491 g/cm³
• Vapor Pressure: 0.0022mmHg at 25°C
• Refractive Index: 1.59
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• CAS DataBase Reference: 5-BROMO-2-(ISOPROPYLAMINO)PYRIMIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: 5-BROMO-2-(ISOPROPYLAMINO)PYRIMIDINE(77476-95-0)
• EPA Substance Registry System: 5-BROMO-2-(ISOPROPYLAMINO)PYRIMIDINE(77476-95-0)

Safety Data

• Hazard Codes: Xi
• Statements: 36
• Safety Statements: 26
• Hazardous Substances Data: 77476-95-0(Hazardous Substances Data)

Usage

General Description

5-Bromo-2-(isopropylamino)pyrimidine is a chemical compound with a unique structure that contains a bromine atom, a pyrimidine ring, and an isopropylamino group. 5-Bromo-2-(isopropylamino)pyrimidine is commonly used in the pharmaceutical industry as an intermediate for the synthesis of various pharmaceutical drugs. It is also used as a building block in the production of agrochemicals and other fine chemicals. 5-Bromo-2-(isopropylamino)pyrimidine is known for its versatile reactivity and potential for forming diverse chemical compounds, making it an important component in the creation of various pharmaceutical and chemical products.

InChI:InChI=1/C7H10BrN3/c1-5(2)11-7-9-3-6(8)4-10-7/h3-5H,1-2H3,(H,9,10,11)

Upstream product

• 4214-72-6 2-isopropylamino-pyrimidine 
• 75-31-0 isopropylamine 
• 62802-38-4 5-fluoro-2-(trifluoromethyl)pyrimidine 
• 32779-36-5 5-Bromo-2-chloropyrimidine 

Downstream Products

• 1360551-67-2 2-[4-(3-{(R)-1-cyclopropyl-1-[4-(2-isopropylamino-pyrimidin-5-yl)-phenyl]-ethyl}-[1,2,4]oxadiazol-5-yl)-pyrazol-1-yl]-N,N-dimethyl-acetamide 

Relevant articles and documents

Design, synthesis, and biological evaluation of 3-(1H-1,2,3-triazol-1-yl) benzamide derivatives as potent pan Bcr-Abl inhibitors including the threonine315←isoleucine315 mutant

A series of 3-(1H-1,2,3-triazol-1-yl)benzamide derivatives were designed and synthesized as new Bcr-Abl inhibitors by using combinational strategies of bioisosteric replacement, scaffold hopping, and conformational constraint. The compounds displayed significant inhibition against a broad spectrum of Bcr-Abl mutants including the gatekeeper T315I and p-loop mutations, which are associated with disease progression in CML. The most potent compounds 6q and 6qo strongly inhibited the kinase activities of Bcr-AblWT and Bcr-AblT315I with IC50 values of 0.60, 0.36 and 1.12, 0.98 nM, respectively. They also potently suppressed the proliferation of K562, KU812 human CML cells, and a panel of murine Ba/F3 cells ectopically expressing either Bcr-AblWT or any of a panel of other Bcr-Abl mutants that have been shown to contribute to clinical acquired resistance, including Bcr-AblT315I, with IC50 values in low nanomolar ranges. These compounds may serve as lead compounds for further development of new Bcr-Abl inhibitors capable of overcoming clinical acquired resistance against imatinib.

BIARYL COMPOUNDS AND METHODS OF USE THEREOF

Provided herein are compounds for treatment of KIT, CSF-1R and/or FLT3 kinase mediated diseases. Also provided are pharmaceutical compositions comprising the compounds and methods of using the compounds and compositions.

Halogeno derivatives of isopropylamino pyrimidine and therapeutic use

The invention relates to new isopropylamino pyrimidine halogeno derivatives of the formula: STR1 in which X represents a fluorine, a chlorine or a bromine atom. These compounds, when X stands for chlorine or bromine, are prepared by reacting, at room temperature and in stoichiometric proportions, 2-isopropylamino pyrimidine on the appropriate N-halogeno succinimide, in the presence of acetic acid.