77483-50-2

Basic information

• Product Name: N-benzyl-2-(3,4-dimethoxyphenyl)acetamide
• Synonyms: N-benzyl-2-(3,4-dimethoxyphenyl)acetamide
• CAS NO: 77483-50-2
• Molecular Formula: C₁₇H₁₉NO₃
• Molecular Weight: 285.33766
• Mol File: 77483-50-2.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: N-benzyl-2-(3,4-dimethoxyphenyl)acetamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-benzyl-2-(3,4-dimethoxyphenyl)acetamide(77483-50-2)
• EPA Substance Registry System: N-benzyl-2-(3,4-dimethoxyphenyl)acetamide(77483-50-2)

Safety Data

• Hazardous Substances Data: 77483-50-2(Hazardous Substances Data)

Upstream product

• 120-14-9 3,4-dimethoxy-benzaldehyde 
• 100-46-9 benzylamine 
• 13939-06-5 molybdenum hexacarbonyl 
• 201669-43-4 N-Benzyl-2-(3,4-dimethoxy-phenyl)-N-trimethylsilanylmethyl-acetamide 
• 93-40-3 (3,4-Dimethoxyphenyl)acetic acid 
• 77483-49-9 Ethyl 3-oxo-4-(3,4-dimethoxyphenyl)butanoate 

Downstream Products

• 107770-10-5 1-benzyl-3-(3,4-dimethoxyphenyl)-2-pyrrolidinone 
• 201669-43-4 N-Benzyl-2-(3,4-dimethoxy-phenyl)-N-trimethylsilanylmethyl-acetamide 
• 144889-05-4 1-Benzyl-5-chloro-4-(3,4-dimethoxy-phenyl)-3,4-dihydro-2H-pyrrolium; chloride 
• 1357480-95-5 N-benzyl-2-(2-iodo-4,5-dimethoxyphenyl)acetamide 

Relevant articles and documents

2-Arylacetamides as Versatile Precursors for 3-Aminoisocoumarin and Homophthalimide Derivatives: Palladium-Catalyzed Cascade Double Carbonylation Reactions

The synthesis of biologically relevant homophthalimide and 3-aminoisocoumarin nuclei via palladium-catalyzed carbonylation of 2-(2-iodoaryl)acetamides has been developed. The degree of N-substitution on the starting amide substrate dictates whether C?N or

Microwave assisted efficient aminocarbonylation of N-tosylhydrazones with molybdenum hexacarbonyl and amines

An efficient aminocarbonylation of N-tosylhydrazones derived from aromatic aldehydes and ketones mediated by molybdenum hexacarbonyl is reported. This method is palladium-free and provides a rapid access to the α-aryl acetamides in moderate to good yields.

Direct synthesis of amides from carboxylic acids and amines using B(OCH2CF3)3

B(OCH2CF3)3, prepared from readily available B2O3 and 2,2,2-trifluoroethanol, is as an effective reagent for the direct amidation of a variety of carboxylic acids with a broad range of amines. In most cases, the amide products can be purified by a simple filtration procedure using commercially available resins, with no need for aqueous workup or chromatography. The amidation of N-protected amino acids with both primary and secondary amines proceeds effectively, with very low levels of racemization. B(OCH2CF3)3 can also be used for the formylation of a range of amines in good to excellent yield, via transamidation of dimethylformamide.

A highly convenient, efficient, and selective process for preparation of esters and amides from carboxylic acids using Fe3+-K-10 montmorillonite clay

In the presence of Fe3+-K-10 montmorillonite clay as a catalyst, aliphatic carboxylic acids selectively produced the corresponding esters in the presence of aromatic carboxylic acids by treatment with alcohols. Both the aliphatic and aromatic carboxylic acids formed the amides by reacting with the aliphatic amines, but only the aliphatic carboxylic acids yielded the anilides by treatment with aromatic amines. The catalyst is recoverable and recyclable.

A rapid and convenient synthesis of amides from aromatic acids and aliphatic amines in dry media under microwave irradiation

The synthesis of amides 2 from the corresponding aromatic acids and aliphatic amines in the presence of catalytic amount of p-toluenesulfonic acid has been reported. The reactions are accelerated with microwave irradiation under solvent-free conditions to afford a high yielding synthesis of amides.