77483-80-8

Usage

Uses

Used in Pharmaceutical Industry:
Hexahydropentalene-1,4-dione is used as a raw material for the synthesis of pharmaceuticals. Its unique structure and versatility in organic synthesis enable the creation of various functionalized products, making it a valuable intermediate in the development of new drugs.
Used in Agrochemical Industry:
Hexahydropentalene-1,4-dione is also used as a raw material for the synthesis of agrochemicals. Its ability to form diverse functionalized products through organic synthesis contributes to the development of new and effective agrochemicals for agricultural applications.
Used in Organic Synthesis:
Hexahydropentalene-1,4-dione is used as a versatile intermediate in organic synthesis for the production of various organic compounds with diverse applications. Its unique structure allows for the creation of a wide range of functionalized products, making it an important building block in the synthesis of complex organic molecules.

Upstream product

• 136749-32-1 3,6-Dihydroxy-1,3a,4,6a-tetrahydro-pentalene-2,5-dicarboxylic acid di-tert-butyl ester 
• 5259-72-3 cyclo-octa-1,5-diene 
• 200725-73-1 octahydropentalene-1,4-diyl diacetate 
• 1552-12-1 1,5-cis,cis-cyclooctadiene 
• 136749-31-0 1,6-di-tert-butyl 3,4-dimethyl 1,3,4,6-hexanetetracarboxylate 

Downstream Products

• 139040-24-7 (r-1H,c-5H)-c-2,c-6-Diphenylbicyclo<3.3.0>octan-2,6-diol 
• 115821-38-0 (2S,3aR,4R,6aS)-4-Methyl-2-(3-oxo-butyl)-hexahydro-pentalen-1-one 
• 77275-08-2 (r-1H,c-5H)-2,6-Diphenylbicyclo<3.3.0>octa-2,6-dien 

Relevant academic research and scientific papers

Polycyclic derivatives and preparation thereof

The invention discloses compounds shown as a formula (I) and a formula (II) and stereoisomers, pharmaceutically acceptable salts, solvates, hydrates, N-oxides and prodrugs thereof, pharmaceutical compositions and preparation methods of the compounds and t

Diversity-oriented approach to spirocycles via ring-closing metathesis

We have demonstrated a simple and an efficient method for the synthesis of spirocycles starting with inexpensive and commercially available carbonyl compounds. Various spirocycles involving spiropropellane derivative have been assembled via ring-closing m

An Improved Synthesis of Bicyclooctane-2,6-dione

The Michael addition of dimethyl malonate (12) to tert-butyl acrylate (11), carried out without solvent, affords the triester 13a in 88percent yield on a kg scale.Selective partial hydrolysis of 13a produces the monoacid 13b almost quantitatively.The Kolbe electrolysis of 13b furnishes the tetraester 7c as a crystalline 1:1 mixture of diastereomers in 62-74percent yield.The Dieckmann condensation of 7c is induced by sodium hydride/tert-butyl alcohol in tetrahydrofuran and yield the enolized β-oxo ester 8c which, on acidic hydrolysis followed by decarboxylation, produces the title diketone 2 in 90percent yield, based on 7c.Thus, the useful diketone 2 is obtained in 46-55percent overall yield on a 100-g scale.Key Words: Malonate, dimethyl- / Acrylate, tert-butyl- / Bicyclooctane, derivatives of / Pentalene, perhydro-, derivatives of / Michael addition / Kolbe electrolysis / Dieckmann condensation