7749-51-1Relevant academic research and scientific papers
Heat shock protein 70 inhibitors. 1. 2,5′-thiodipyrimidine and 5-(phenylthio)pyrimidine acrylamides as irreversible binders to an allosteric site on heat shock protein 70
Kang, Yanlong,Taldone, Tony,Patel, Hardik J.,Patel, Pallav D.,Rodina, Anna,Gozman, Alexander,Maharaj, Ronnie,Clement, Cristina C.,Patel, Maulik R.,Brodsky, Jeffrey L.,Young, Jason C.,Chiosis, Gabriela
, p. 1188 - 1207 (2014/03/21)
Heat shock protein 70 (Hsp70) is an important emerging cancer target whose inhibition may affect multiple cancer-associated signaling pathways and, moreover, result in significant cancer cell apoptosis. Despite considerable interest from both academia and
NOVEL FUSED CYCLIC COMPOUND AND USE THEREOF
-
Page/Page column 153-154, (2010/12/29)
A compound represented by the formula (I): wherein each symbol is as defined in the specification, and a salt thereof have a GPR40 receptor activation action and is useful as an insulin secretagogue or a prophylactic or therapeutic drug for diabetes and the like.
Substituted pyrimidine derivatives
-
Page/Page column 13, (2008/06/13)
The present invention relates to pyrimidine derivatives of the general formula I or salts thereof and their use.
PYRIMIDINE DERIVATIVES AND THEIR USE AS KCNQ POTASSIUM CHANNELS OPENERS
-
Page/Page column 31, (2008/06/13)
The present invention relates to pyrimidine derivatives of the general formula I or salts thereof and their use as openers of the KNCQ family potassium ion channels, particularly in the treatment of epilepsy.
