77506-96-8Relevant academic research and scientific papers
One-Pot SNAr/Direct Pd-Catalyzed CH Arylation Functionalization of Pyrazolo[1,5-a]pyrimidine at the C3 and C7 Positions
Loubidi, Mohammed,Manga, Catherine,Tber, Zahira,Bassoude, Ibtissam,Essassi, El Mokhtar,Berteina-Raboin, Sabine
, p. 3936 - 3942 (2018)
An efficient and original synthesis of various 3,7-substituted pyrazolo[1,5-a]pyrimidines is reported. First, a two-step process by an SNAr amination followed by a Pd-catalyzed direct CH-arylation was developed, then a parallel single-pot SNAr amination/CH arylation sequence was performed starting from 7-chloro-5-methyl-2-phenylpyrazolo[1,5-a]pyrimidine to obtain highly functionalized products with good yields.
PYRAZOLOPYRIMIDINYL INHIBITORS OF UBIQUITIN-ACTIVATING ENZYME
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Paragraph 0288, (2013/08/28)
Disclosed are chemical entities that inhibit ubiquitin-activating enzyme (UAE), each of which is a compound of Formula I: or a pharmaceutically acceptable salt thereof, wherein Y is and W, Z, XY, RY1, RY2 and RY3 are defined herein; pharmaceutical compositions comprising the chemical entities; and methods of using the chemical entities. These chemical entities are useful for treating disorders, particularly cell proliferation disorders, including cancers.
