77515-93-6Relevant academic research and scientific papers
Organocopper conjugate addition reaction in the presence of trimethylchlorosilane
Alexakis,Berlan,Besace
, p. 1047 - 1050 (1986)
In the presence of TMSCl, the conjugate addition of organocuprates to various α, β-unsaturated esters, amides, ketones and nitriles is greatly improved. The reaction is faster, the yields are very high and the reaction is very clean.
Selective 1,4-reduction of α,β-unsaturated carbonyl compounds by combined use of bis(l,3-diketonato)cobait(II) complex and diisobutylaluminum hydride
Ikeno, Taketo,Kimura, Tomomi,Ohtsuka, Yuhki,Yamada, Tohru
, p. 96 - 98 (2007/10/03)
By the combined use of Co(acac)2 with DIBAL, various α,β-unsaturated carbonyl compounds such as enones, α,β-unsaturated carboxylates and carboxamides were selectively reduced in a 1,4-manner to obtain the corresponding 1,4-reduced products in good-to-high yields. Thieme.
TANDEM-CONJUGATE ADDITION-α-ADDITION OF UNSATURATED AMIDES. SYNTHETIC METHODOLOGY.
Mpango, G. B.,Mahalanabis, K. K.,Mahdavi-Damghani, Z.,Snieckus, V.
, p. 4823 - 4826 (2007/10/02)
1,4-Addition of RLi, RMgX, and (RS)2CHLi reagents to unsaturated amides 2a-c followed by α-alkylation is shown to constitute a general and efficient synthetic procedure for the formation of two C-C bonds in a single step.
