77516-32-6Relevant academic research and scientific papers
Synthesis of alkylated indolizidine alkaloids via Pummerer mediated cyclization: synthesis of (±)-indolizidine 167B, (±)-5-butylindolizidine and (±)-monomorine I
Kuhakarn, Chutima,Seehasombat, Phachanee,Jaipetch, Thaworn,Pohmakotr, Manat,Reutrakul, Vichai
, p. 1663 - 1670 (2008/09/17)
The syntheses of indolizidine alkaloids, i.e., (±)-coniceine, (±)-indolizidine 167B, (±)-5-butylindolizidine and (±)-monomorine I via Pummerer cyclization are described. The key step is the transformation of lactam sulfoxide to bicyclic lactam via the Pum
The preparation of synthetically useful carbonyl-protected δ- and ε-lithio ketones via reductive lithiation
Zhu, Shirong,Cohen, Theodore
, p. 17607 - 17624 (2007/10/03)
The aromatic radical-anion induced reductive lithiation of the acetals or thioacetals of δ- and ε-(phenylthio)ketones provides δ- and ε-lithioketone equivalents. Primary and tertiary organolithiums have been generated and the ketone function may be part o
Intramolecular Sulfur Ylide Additions to Ketones
Crandall, Jack K.,Magaha, H. Steve,Henderson, Mark A.,Widener, Rexford K.,Tharp, Gregg A.
, p. 5372 - 5380 (2007/10/02)
Methodology is described for the annulation of five-membered carboxylic rings onto cycloalkanones, using an intramolecular sulfur ylide reaction.Epoxybicycloalkanes (x = 3, 4, 5, 6) were obtained from cycloalkanones via the corresponding 2-3-(phen
INTRAMOLECULAR SULFOR-YLIDE ADDITIONS TO KETONES. A CYCLOPENTANE ANNULATION
Crandall, J. K.,Magaha, H. S.,,Widener, R. K.,Tharp, G. A.
, p. 4807 - 4810 (2007/10/02)
Various 2-(3'-phenylthiopropyl)cycloalkanones were prepared from the corresponding ketones and subjected to S-alkylation by triethyloxonium tetrafluoroborate followed by potassium tert-butoxide treatment to give bicyclic epoxides with new five-membered ca
