7752-62-7

Usage

Uses

Used in Organic and Medicinal Chemistry:
(3-cyanopropyl)triphenylphosphonium is used as a ligand or reagent in organic and medicinal chemistry for its ability to facilitate various synthetic reactions. Its unique structure and properties make it a valuable component in the synthesis of complex organic molecules and pharmaceutical compounds.
Used in Phase-Transfer Catalysis:
(3-cyanopropyl)triphenylphosphonium is used as a phase-transfer catalyst due to its amphiphilic nature, which allows it to promote reactions between compounds in different phases, such as between an aqueous and an organic phase. This enhances the efficiency and selectivity of certain chemical reactions.
Used in Pharmaceutical Development:
(3-cyanopropyl)triphenylphosphonium is used as a potential component in the development of new pharmaceuticals, leveraging its unique chemical properties to create novel drug candidates with improved efficacy and reduced side effects.
Used in Anti-Microbial Applications:
(3-cyanopropyl)triphenylphosphonium is studied for its potential as an anti-microbial agent, with the aim of developing new treatments for bacterial and fungal infections. Its ability to interact with biological systems makes it a promising candidate for this application.

InChI:InChI=1/C22H21NP/c23-18-10-11-19-24(20-12-4-1-5-13-20,21-14-6-2-7-15-21)22-16-8-3-9-17-22/h1-9,12-17H,10-11,19H2/q+1

Upstream product

• 603-35-0 triphenylphosphine 
• 5332-06-9 4-bromobutanenitrile 

Downstream Products

• 349544-17-8 (4Z,6S)-6-[(tert-butyldiphenylsilyl)oxy]-4-heptenenitrile 
• 854001-09-5 4-cyclohexylidenebutanenitrile 
• 144270-76-8 (Z)-5-phenylpent-4-enenitrile 
• 854001-11-9 (Z)-5-(4-methoxyphenyl)pent-4-enenitrile 
• 154777-53-4 cis-5-(4-isopropylphenyl)pent-4-enylamine 
• 154777-31-8 cis-N-(benzenesulfenyl)-5-(4-isopropylphenyl)pent-4-enylamine 

Relevant academic research and scientific papers

Palladium-Catalyzed Regioselective C-H Iodination of Unactivated Alkenes

A palladium-catalyzed C-H iodination of unactivated alkenes is reported. A picolinamide directing group enables the regioselective functionalization of a wide array of olefins to furnish iodination products as single stereoisomers. Mechanistic investigations suggest the reversible formation of a six-membered alkenyl palladacycle intermediate through a turnover-limiting C-H activation.

Photo-Organocatalytic Enantioselective Radical Cascade Reactions of Unactivated Olefins

Radical cascade processes are invaluable for their ability to rapidly construct complex chiral molecules from simple substrates. However, implementing catalytic asymmetric variants is difficult. Reported herein is a visible-light-mediated organocatalytic strategy that exploits the excited-state reactivity of chiral iminium ions to trigger radical cascade reactions with high enantioselectivity. By combining two sequential radical-based bond-forming events, the method converts unactivated olefins and α,β-unsaturated aldehydes into chiral adducts in a single step. The implementation of an asymmetric three-component radical cascade further demonstrates the complexity-generating power of this photochemical strategy.

NOVEL CYCLOSPORIN DERIVATIVES AND USES THEREOF

A compound of the Formula (I) is disclosed: (I) or pharmaceutically acceptable salt thereof, wherein the symbols are as defined in the specification. Also described are a pharmaceutical composition comprising the same and a method for treating or preventing viral infections, inflammation, dry eye, central nervous disorders, cardiovascular diseases, cancer, obesity, diabetes, muscular dystrophy, lung, and liver, and kindey diseases, and hair loss using the same.

Annulations via dianions: Formation of five-, six- and seven-membered rings

Phosphonium salts bearing an electron-withdrawing group at the γ-position form dianions that react with bis-electrophiles to generate five-, six-, and seven- membered rings.

AMINE COMPOUNDS AND USE THEREOF

It is intended to provide novel amine compounds which are efficacious against diseases such as infection with HIV virus, rheumatism and cancer metastasis. Namely, amine compounds represented by the following general formula (1):In a typical case, A1 and A2 represent each an optionally substituted monocyclic or polycyclic aromatic heterocycle; W represents cyclic C3-10 alkylene, an optionally substituted monocyclic or polycyclic aromatic heterocycle, a monocyclic or polycyclic aromatic ring or a partly saturated polycyclic aromatic ring; X represents O, CH2, C(=O) or NR11; and D is a group represented by the following general formula (4) or (6).-Q-Y-BIn the formula (6), Q represents a single bond, S, O or NR12; and Y is a group represented by the following general formula (7). z represents an optionally substituted monocyclic or polycyclic aromatic ring. In the formula (6), B represents NR25R26. In the above formulae, R1 to R26 each represents hydrogen, alkyl, alkenyl or alkynyl.

Generation of Aminyl Radicals using Sulfenamides as Synthetic Precursors

Sulfenamides are synthesised from reaction between amines and N-(benzenesulfenil)-phthalimide or benzenesulfenyl chloride.The sulfenamides undergo reaction with tributyltin hydride to yield aminyl radicals which can be cyclised onto suitable alkenes. Key Words: sulfenamides; aminyl radicals; tributyltin hydride; radical-cyclisation; N-(benzenesulfenyl)phthalimide

Synthesis of Chiral Vinylglycines

(R)- or (S)-benzyl 4-formyl-2,2-dimethyl-3-oxazolidinecarboxylate (7a) and (R)- or (S)-1,1-dimethylethyl 4-formyl-2,2-dimethyl-3-oxazolidinecarboxylate (7b), readily available from serine, react with Wittig reagents to give alkenes 8.Selective deprotection followed by oxidation of the resulting unsaturated amino alcohols 9 provides vinylglycines 5 of defined configuration (>95percent ee) and double-bond geometry.D-Vinylglycines are obtained from L-serine, and conversely, D-serine gives β,γ-unsaturated amino acids with the L configuration.The double-bond geometry is controlled by the nature of the phosphorous ylide employed.The scope and limitations of this new methodology for the preparation of chiral vinylglycines is examined.