77521-29-0 Usage
Uses
Different sources of media describe the Uses of 77521-29-0 differently. You can refer to the following data:
1. A potent and selective agonist of the excitatory neurotransmitter L-glutamic Acid. AMPA does not interfere with binding sites for kainic acid in vitro, and AMPA- induced neuronal excitation is not significantly affected by NMDA antagonists
2. AMPA is the defining agonist for the AMPA subgroup of ionotropic glutamate receptors, which mediate excitatory neurotransmission. Because AMPA does not interfere with binding sites for kainic acid or NMDA , it can be used to distinguish AMPA receptor-specific activity that contributes to a neuronal response. (R,S)-AMPA contains an equal mixture of the active (S)-enantiomer and the inactive (R)-enantiomer.
Biological Activity
More water soluble hydrobromide salt of ( RS )-AMPA ((RS)-a-Amino-3-hydroxy-5-methyl-4-isoxazolepropionicacid ).
Check Digit Verification of cas no
The CAS Registry Mumber 77521-29-0 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 7,7,5,2 and 1 respectively; the second part has 2 digits, 2 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 77521-29:
(7*7)+(6*7)+(5*5)+(4*2)+(3*1)+(2*2)+(1*9)=140
140 % 10 = 0
So 77521-29-0 is a valid CAS Registry Number.
InChI:InChI=1/C7H10N2O4/c1-3-4(6(10)9-13-3)2-5(8)7(11)12/h5H,2,8H2,1H3,(H,9,10)(H,11,12)/t5-/m0/s1
77521-29-0Relevant articles and documents
An efficient and general enantioselective synthesis of some isoxazole- containing analogues of the neuroexcitant glutamic acid
Pajouhesh, Hassan,Curry, Kenneth
, p. 2757 - 2760 (1998)
Isoxazole amino acids are an important class of neuroexcitant which are difficult to prepare in enantiopure form. Diastereoselective alkylation of the enantiomerically pure glycine derivative, tert-butoxycarbonyl-2-(tert- butyl)-3-methyl-4-oxo-1-imidazolidinecarboxylate (Boc-BMI) with 4- bromomethyl-2-methoxymethyl-5-methylisoxazolin-5-one 5 or 5-bromomethyl-4- bromo-3-methoxyisoxazole, gives intermediates which under mild hydrolysis conditions produce the amino acids (S)- and (R)-bromohomoibotenic acid and (S)- and (R)-2-amino-3-(3-hydroxy-5-methylisoxazol-4-yl) propionic acid with e.e. >99%.
