77522-28-2Relevant academic research and scientific papers
Synthesis and insecticidal activity of mesoionic pyrido[1,2-α]pyrimidinone derivatives containing a neonicotinoid moiety
Pan, Jianke,Yu, Lu,Liu, Dengyue,Hu, Deyu
, (2018/05/30)
Mesoionic pyrido[1,2-α]pyrimidinone derivatives containing a neonicotinoid moiety were designed, synthesized, and evaluated for their insecticidal activity. Some of the title compounds showed remarkable insecticidal properties against Aphis craccivora. Compound I13 exhibited satisfactory insecticidal activity against A. craccivora. Meanwhile, label-free proteomics analysis of compound I13 treatment identified a total of 821 proteins. Of these, 35 proteins were up-regulated, whereas 108 proteins were down-regulated. Differential expressions of these proteins reflected a change in cellular structure and metabolism.
Mesoionic Xanthine Analogues: Phosphodiesterase Inhibitory and Hypotensive Activity
Glennon, Richard A.,Rogers, Michael E.,Smith, J. Doyle,El-Said, M. K.,Egle, John L.
, p. 658 - 661 (2007/10/02)
Several mesoionic thiazolopyrimidines and mesoionic 1,3,4-thiadiazolopyrimidines were evaluated as inhibitors of cyclic-AMP phosphodiesterase.While small alkyl substituents at the 6 position have no significant effect on activity, phenyl and benzyl substituents enhance activity.Mesoionic structures such as 1 (R2 = H; R8 = Et) possess 20 to 40 times activity of theophylline when the R6 substituent is phenyl or 4-chlorobenzyl.Methyl and ethyl substitution at the 2 position essentially abolishes activity.Although plagued by solubility problems, several of the mesoionic derivatives were found to display weak hypotensive effects in vivo.
