775238-72-7Relevant academic research and scientific papers
Novel synthetic azaacridine analogues as topoisomerase 1 inhibitors
Luan, Xudong,Gao, Chunmei,Sun, Qinsheng,Tan, Chunyan,Liu, Hongxia,Jin, Yibao,Jiang, Yuyang
, p. 728 - 729 (2011/08/06)
Novel azaacridine analogues were synthesized and their antiproliferative activities against K562 and HepG-2 cell lines were evaluated, among which compound 5a was found to display good cytotoxicity. UVvisible spectral absorbance measurements showed that 5a can bind with calf thymus DNA (ct DNA). A relaxation assay indicated that 5a inhibits topoisomerase 1 activity.
