77528-48-4

Upstream product

• 103057-51-8 hypochlorous acid 4-methylbenzene sulfonic anhydride 
• 77528-47-3 4,5,6,7-tetrahydro-1,3-benzothiazol-4-ylmethanamine 
• 98-59-9 p-toluenesulfonyl chloride 
• 77528-97-3 2-Isopropyl-5-hydroxymethyl-4,5,6,7-tetrahydrobenzo[d]thiazole 
• 108-20-3 di-isopropyl ether 
• 1655-07-8 ethyl 2-oxocyclohexane carboxylate 
• 30132-23-1 ethyl 3-bromo-2-oxocyclohexanecarboxylate 

Relevant academic research and scientific papers

A convenient synthesis of 4-aminomethyl-4,5,6,7-tetrahydro-1,3-benzothiazole arginine side-chain mimetics

A convenient synthesis of novel 4-aminomethyl-4,5,6,7-tetrahydro-1,3-benzothiazole arginine side-chain mimetics designed for incorporation into thrombin inhibitors is reported.

Synthesis of aminoiderivatives of 4,5,6,7-tetrahydro-benzothiazole. II. 4, 5 and 6-aminomethyl derivatives with cardiovascular activity

The ethyl esters of 4,5,6,7-tetrahdyro-benzothiazolyl-4 carboxylic acids were synthesized from corresponding ethyl 1-oxo-2 bromo-cyclohexane-carboxylates. Their reduction to alcohols, which were then transformed into tosylates, leads to the aminomethyl derivatives. These derivatives are practically devoid of antihistaminic H2 and dopaminergic activities but have interesting cardiovascular properties.

4,5 or 6-Alkylaminoalkyl-2-alkyl-4,5,6,7-tetrahydro benzo[d]thiazoles

This invention relates to compounds of the formula (I): STR1 in which: R is selected from hydrogen and C1-6 alkyl and R' is selected from hydrogen and C1-6 alkyl; and their pharmaceutically acceptable acid addition salts. Said compounds are therapeutically useful for the treatment of circulatory insufficiencies.