77528-71-3

Upstream product

• 103057-51-8 hypochlorous acid 4-methylbenzene sulfonic anhydride 
• 77528-70-2 2-Methyl-6-hydroxymethyl-4,5,6,7-tetrahydrobenzo[d]thiazole 
• 77528-69-9 2-Methyl-6-ethoxycarbonyl-4,5,6,7-tetrahydrobenzo[d]thiazole 
• 39086-05-0 ethyl 3-bromo-4-oxocyclohexanecarboxylate 
• 17159-79-4 ethyl 4-oxocyclohexane-1-carboxylate 
• 3618-04-0 4-hydroxycyclohexyl carboxylic acid ethyl ester 
• 120-47-8 Ethyl 4-hydroxybenzoate 

Relevant academic research and scientific papers

Synthesis of aminoiderivatives of 4,5,6,7-tetrahydro-benzothiazole. II. 4, 5 and 6-aminomethyl derivatives with cardiovascular activity

The ethyl esters of 4,5,6,7-tetrahdyro-benzothiazolyl-4 carboxylic acids were synthesized from corresponding ethyl 1-oxo-2 bromo-cyclohexane-carboxylates. Their reduction to alcohols, which were then transformed into tosylates, leads to the aminomethyl derivatives. These derivatives are practically devoid of antihistaminic H2 and dopaminergic activities but have interesting cardiovascular properties.

4,5 or 6-Alkylaminoalkyl-2-alkyl-4,5,6,7-tetrahydro benzo[d]thiazoles

This invention relates to compounds of the formula (I): STR1 in which: R is selected from hydrogen and C1-6 alkyl and R' is selected from hydrogen and C1-6 alkyl; and their pharmaceutically acceptable acid addition salts. Said compounds are therapeutically useful for the treatment of circulatory insufficiencies.