775307-07-8

Upstream product

• 87318-96-5 (4S)-4-((2R)-2-hydroxypent-4-enyl)-2,2-dimethyl-1,3-dioxolane 
• 775307-03-4 (3S,5S)-5-(tert-Butyl-dimethyl-silanyloxy)-3-(2-methoxy-ethoxymethoxy)-oct-7-ynoic acid methoxy-methyl-amide 
• 775307-67-0 (3S,5S)-5-(tert-Butyl-dimethyl-silanyloxy)-3-(2-methoxy-ethoxymethoxy)-oct-7-ynoic acid methyl ester 
• 775307-59-0 2,2-Dimethyl-propionic acid (2S,4R)-2-methanesulfonyloxy-4-(2-methoxy-ethoxymethoxy)-hept-6-enyl ester 
• 775307-01-2 tert-Butyl-[(1S,3R)-3-(2-methoxy-ethoxymethoxy)-1-prop-2-ynyl-hex-5-enyloxy]-dimethyl-silane 
• 775307-65-8 (3S,5S)-5-(tert-Butyl-dimethyl-silanyloxy)-3-(2-methoxy-ethoxymethoxy)-oct-7-ynal 
• 775307-57-8 2,2-Dimethyl-propionic acid (2S,4R)-2-hydroxy-4-(2-methoxy-ethoxymethoxy)-hept-6-enyl ester 
• 775307-63-6 (4S,6R)-6-(2-Methoxy-ethoxymethoxy)-non-8-en-1-yn-4-ol 
• 775307-53-4 (S)-4-[(R)-2-(2-Methoxy-ethoxymethoxy)-pent-4-enyl]-2,2-dimethyl-[1,3]dioxolane 
• 775307-55-6 (2S,4R)-4-(2-Methoxy-ethoxymethoxy)-hept-6-ene-1,2-diol 
• 775306-99-5 (R)-2-[(R)-2-(2-Methoxy-ethoxymethoxy)-pent-4-enyl]-oxirane 
• 775307-05-6 (E)-(3S,5S)-5-(tert-Butyl-dimethyl-silanyloxy)-8-iodo-3-(2-methoxy-ethoxymethoxy)-oct-7-enoic acid methoxy-methyl-amide 
• 397886-47-4 (E)-(5R,6R)-6-(4-Methoxy-benzyloxy)-5-methyl-oct-2-en-7-yn-1-ol 

Relevant academic research and scientific papers

Synthetic studies aimed at (-)-cochleamycin A. Evaluation of late-stage macrocyclization alternatives

An efficient route to the fully functionalized ABC ring systems of the unnatural enantiomer of cochleamycin A was developed. L-(-)-Malic and L-(-)-ascorbic acids served well as starting materials for the two building blocks used to construct an (E,Z,E)-1,