77532-90-2

Basic information

• Product Name: 2-CYANO-4-FLUOROBENZALDEHYDE
• Synonyms: 2-CYANO-4-FLUOROBENZALDEHYDE;Benzonitrile, 5-fluoro-2-formyl- (9CI);5-Fluoro-2-formylbenzonitrile;C90154
• CAS NO: 77532-90-2
• Molecular Formula: C₈H₄FNO
• Molecular Weight: 149.12
• Product Categories: HALIDE;ALDEHYDE
• Mol File: 77532-90-2.mol
• Article Data: 3

Chemical Properties

• Melting Point: 120-122 °C
• Boiling Point: 286.3 °C at 760 mmHg
• Flash Point: 126.9 °C
• Appearance: /
• Density: 1.25 g/cm³
• Vapor Pressure: 0.00266mmHg at 25°C
• Refractive Index: 1.527
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• CAS DataBase Reference: 2-CYANO-4-FLUOROBENZALDEHYDE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-CYANO-4-FLUOROBENZALDEHYDE(77532-90-2)
• EPA Substance Registry System: 2-CYANO-4-FLUOROBENZALDEHYDE(77532-90-2)

Safety Data

• Hazardous Substances Data: 77532-90-2(Hazardous Substances Data)

Usage

General Description

2-CYANO-4-FLUOROBENZALDEHYDE is a chemical compound with the molecular formula C8H5FNO. It is a pale yellow solid with a bitter almond odor. It is commonly used as a building block and intermediate in the synthesis of pharmaceuticals and agrochemicals. 2-CYANO-4-FLUOROBENZALDEHYDE is also used in the production of dyes and pigments. It is important to handle 2-CYANO-4-FLUOROBENZALDEHYDE with caution, as it may be harmful if swallowed, inhaled, or absorbed through the skin, and can cause irritation to the skin and eyes.

InChI:InChI=1/C8H4FNO/c9-8-2-1-6(5-11)7(3-8)4-10/h1-3,5H

Upstream product

• 77532-85-5 2-(dibromomethyl)-5-fluorobenzonitrile 

Downstream Products

• 1049693-80-2 2-(2,2-dibromovinyl)-5-fluorobenzonitrile 
• 1233881-24-7 (Z)-6-fluoro-3-(3-phenylprop-2-ynylidene)isoindolin-1-one 

Relevant articles and documents

Tetrazole derivative and preparation thereof, pharmaceutical composition containing tetrazole derivative and application of tetrazole derivative

The invention discloses a tetrazole derivative having a structure represented by a general formula I, wherein R1 is H, a C1-C3 alkyl chain or a halogenated alkyl chain. The invention also discloses acomposition containing the tetrazole derivative and an application of the tetrazole derivative in preparation of medicines for preventing and resisting cerebral apoplexy. Repeated experiments prove that the compound has an obvious inhibition effect on ADP-induced platelet aggregation activity, and has a good protection effect on OGD/R-damaged primary mouse nerve cell models and good rat oral medicine pharmacokinetic properties. Therefore, the compound disclosed by the invention can be used as a neuroprotective agent to be applied to medicines for treating and preventing cerebral apoplexy.

A tandem elimination-cyclization-suzuki approach: Efficient one-pot synthesis of functionalized (Z)-3-(arylmethylene)isoindolin-1-ones

(Chemical Equation Presented) A novel and efficient one-pot regioselective elimination-cyclization-Suzuki approach was developed to afford (Z)-3-arylmethyleneisoindolin-1-ones in good to excellent yields from easily accessible o-gem-dihalovinylbenzamides and organoboron reagents.