775322-46-8Relevant academic research and scientific papers
5-sulfonamido-substituted indolinone compounds as protein kinase inhibitors
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Page/Page column 25, (2010/02/08)
The present invention relates to 5-sulfonamido substituted indolinones that modulate the activity of protein kinases (“PKs”). The compounds of this invention are therefore useful in treating disorders related to abnormal PK activity. Pharmaceutical compositions comprising these compounds, methods of treating diseases utilizing pharmaceutical compositions comprising these compounds and methods of preparing them are also disclosed.
Sulfonamide substituted indolinones as inhibitors of DNA dependent protein kinase (DNA-PK)
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Page 21, (2010/02/10)
The present invention relates generally to the field of radiosensitizing agents which are capable of enhancing radiotherapy by inhibiting DNA-PK (DNA-protein kinase). In particular, it relates to sulfonamide substituted indolinones which inhibit DNA-PK.
