775331-65-2

Usage

Uses

Used in Pharmaceutical Industry:
(2-Amino-5-chloro-3-methyl-phenyl)-methanol is used as a chemical intermediate for the synthesis of various pharmaceuticals. Its unique structure allows it to be a key component in the development of new drugs and medications, contributing to advancements in healthcare and medicine.
Used in Organic Compounds Synthesis:
In the field of organic chemistry, (2-Amino-5-chloro-3-methyl-phenyl)-methanol is utilized as an intermediate for synthesizing other organic compounds. Its versatility in chemical reactions makes it valuable for creating a wide range of products, from dyes to agrochemicals, expanding its applications across different industries.

Upstream product

• 20776-67-4 2-amino-5-chloro-3-methylbenzoic acid 

Downstream Products

• 948289-20-1 6-chloro-2,8-dimethylquinoline 
• 1415592-54-9 6-chloro-8-[(2,6-difluoro-benzylcarbamoyl)-methyl]-2-oxo-1,2-dihydro-quinoline-3-carboxylic acid 
• 1415596-27-8 methyl 6-chloro-8-(2-(2,6-difluorobenzylamino)-2-oxoethyl)-2-methoxyquinoline-3-carboxylate 
• 1415592-52-7 8-(benzylamino-methyl)-6-chloro-2-oxo-1,2-dihydro-quinoline-3-carboxylic acid 
• 1415597-80-6 N-benzyl-8-((benzylamino)methyl)-6-chloro-2-oxo-1,2-dihydroquinoline-3-carboxamide 
• 1415596-25-6 N-benzyl-8-((benzylamino)methyl)-6-chloro-2-methoxyquinoline-3-carboxamide 
• 1415592-51-6 6-chloro-8-[(2-chloro-benzylcarbamoyl)-methyl]-2-oxo-1,2-dihydro-quinoline-3-carboxylic acid 
• 1415592-21-0 8-{[benzyl(methyl)amino]methyl}-6-chloro-2-oxo-1,2-dihydroquinoline-3-carboxylic acid 
• 1415595-88-8 methyl 8-((benzyl(methyl)amino)methyl)-6-chloro-2-methoxyquinoline-3-carboxylate 
• 1415592-19-6 6-chloro-8-[(benzylcarbamoyl)-methyl]-2-oxo-1,2-dihydro-quinoline-3-carboxylic acid 
• 1415595-86-6 methyl 8-(2-(benzylamino)-2-oxoethyl)-6-chloro-2-methoxyquinoline-3-carboxylate 
• 1373758-68-9 N-(2-(((tert-butyl)amino)methyl)-4-chloro-6-methylphenyl)-3-bromo-1-(3-chloropyridin-2-yl)-1H-pyrazole-5-carboxamide 
• 1373758-67-8 3-bromo-N-(4-chloro-2-((isopropylamino)methyl)-6-methylphenyl)-1-(3-chloropyridin-2-yl)-1H-pyrazole-5-carboxamide 
• 1373758-66-7 3-bromo-N-(4-chloro-2-methyl-6-((methylamino)methyl)phenyl)-1-(3-chloropyridin-2-yl)-1H-pyrazole-5-carboxamide 

Relevant academic research and scientific papers

A [4+3] Cycloaddition Reaction of Aza-ortho-quinone Methides with C,N-Cyclic Azomethine Imines for Synthesis of 1,2,4-Triazepines

The base-induced formal [4+3] cycloaddition reaction of C,N-cyclic azomethine imines with aza-ortho-quinone methides, generated in situ, is reported. This protocol provided an efficient method for the synthesis of biologically important 1,2,4-triazepine derivatives, with a wide substrate scope and excellent functional-group tolerance, and it gives moderate to excellent yields under mild conditions. Several of the derivatives exhibited in vitro antitumor activities against the A2780 cell line in a screening of the cancer cell lines HCT-116, H2228, and A2780 by an MTT assay.

Synthesis and pesticidal activities of novel anthranilic diamides containing pyridylpyrazole and iminodithiocarbamate or thiosemicarbazone motifs

A series of novel anthranilic diamide derivatives containing pyridylpyrazole and iminodithiocarbamate or thiosemicarbazone motifs were synthesized via multi-step reactions. The structures of seven title compounds (methyl 2-(2-(3-bromo-1-(3-chloropyridin-2-yl)-1H-pyrazole-5-carboxamido)-5-chloro-3- methylbenzylidene)hydrazinecarbodithioate 7 and 3-bromo-N-(2-((2-substitutedcarbamothioylhydrazono)methyl)-4-chloro-6-methylphenyl)-1-(3-chloropyridin-2-yl)-1H-pyrazole-5-carboxamide 8a-8f) were confirmed by melting points, IR, 1H NMR, 13C NMR, and HRMS. The bioassays showed that some of the compounds exhibited modest insecticidal activities against oriental armyworm (Mythimna separata Walker), particularly, compound 8b (3-bromo-N-(4-chloro-2-methyl-6-((2-(methylcarbamothioyl)hydrazono)methyl)phenyl)-1-(3-chloropyridin-2-yl)-1H-pyrazole-5-carboxamide) held 100% and 30% larvicidal activity at the concentration of 25 mg/L and 10 mg/L, respectively. In addition, several compounds displayed favorable fungicidal activities against Alternaria solani Sorauer and Physalospora piricola at 50 μg/mL, and were comparable with the controls Chlorothalonil and Triadimefon. The results in this paper will provide important information for further research and development of sulfur-containing heterocyclic agrochemicals.

Synthesis of quinolines and naphthyridines: Via catalytic retro-aldol reaction of β-hydroxyketones with ortho -aminobenzaldehydes or nicotinaldehydes

A Cu(i)-catalyzed retro-aldol reaction of β-hydroxyketones with ortho-aminobenzaldehydes and nicotinaldehydes is reported that produces a range of quinolines and naphthyridines with high efficiency and selectivity. This reaction uses β-hydroxyketones as a regiospecific ketone-protected enolate source via copper-catalyzed retro-aldol Cα-Cβ bond cleavage. The in situ generated copper enolate undergoes kinetically favorable cyclization with ortho-amino aryl aldehydes to produce quinolines and naphthyridines in a chemo- and regioselective manner. The mild and weakly basic reaction conditions also suppress possible side reactions of benzaldehydes under strongly basic conditions, resulting in improved reaction yields.

Synthesis and insecticidal evaluation of novel N- pyridylpyrazolecarboxamides containing cyano substituent in the ortho-position

In an attempt to search for potent insecticides targeting the ryanodine receptor (RyR), a series of novel N-pyridylpyrazolecarboxamides containing cyano substituent in the ortho-position were designed and synthesized. Their insecticidal activities of targ

GLYCINE B ANTAGONISTS

The invention relates to 2(1H)-quinolinone derivatives of formula (I) as well as their pharmaceutically acceptable salts. The invention further relates to a process for the preparation of such compounds. The compounds of the invention are glycine B antagonists and are therefore useful for the control and prevention of various disorders, including neurological disorders.

Gold(I)-catalyzed unprecedented rearrangement reaction between 2-aminobenzaldehydes with propargyl amines: An expedient route to 3-aminoquinolines

Access to aminoquinolines: A gold(I)-catalyzed unprecedented rearrangement reaction between 2-aminobenzaldehydes with propargyl amine was studied. The study provided, for the first time, direct access to 3-aminoquinolines in one step starting from readily available starting materials (see scheme). Elegantly designed experiments were employed to unravel the mechanism of this unprecedented rearrangement, which are corroborated by DFT calculations.

Synthesis and insecticidal evaluation of novel N- pyridylpyrazolecarboxamides containing different substituents in the ortho-position

In order to look for novel insecticides containing N-pyridylpyrazole, ten novel pyrazolecarboxamides containing different ortho-substituents in the aniline part were synthesized, and their structures were characterized by 1H NMR, 13C

BENZOPYRAN COMPOUNDS USEFUL FOR TREATING INFLAMMATORY CONDITIONS

The subject invention concerns methods and compounds that have utility in the treatment of a condition associated with cyclooxygenase-2 mediated disorders. Compounds of particular interest are benzopyrans and their analogs defined by formula (1). Wherein Z, X, R1, R2, R3, and R4 are as described in specification.

CHROMENE DERIVATIVES AS ANTI-INFLAMMATORY AGENTS

The subject invention concerns methods and compounds that have utility in the treatment of a condition associated with cyclooxygenase-2 mediated disorders. Compounds of particular interest are benzopyrans and their analogs defined by formula (I). Wherein Z, X, R1, R2, R3, and R4 are as described in the specification.