775339-71-4Relevant academic research and scientific papers
Structure-based parallel medicinal chemistry approach to improve metabolic stability of benzopyran COX-2 inhibitors
Xing, Li,Hamper, Bruce C.,Fletcher, Theresa R.,Wendling, Jay M.,Carter, Jeffery,Gierse, James K.,Liao, Subo
, p. 993 - 996 (2011)
Combination of the structure-based design and solid-phase parallel synthesis provided an integrated approach to rapidly develop the structure-activity relationship of benzopyran COX-2 inhibitors. Binding free energies predicted by free energy perturbation
