775349-54-7 Usage
Uses
Used in Pharmaceutical Research:
MPEP is used as a research compound for studying the role of mGluR5 receptors in neurological and psychiatric disorders. Its ability to selectively target these receptors aids in understanding their involvement in various conditions and the development of potential treatments.
Used in Alcohol Addiction Treatment:
MPEP is used as a potential therapeutic agent for the treatment of alcohol addiction. It has been shown to reduce alcohol self-administration and reinforcing properties in animal models, indicating its effectiveness in managing alcohol-seeking behavior and addiction.
Used in Fragile X Syndrome Treatment:
MPEP is used as a potential treatment for fragile X syndrome, a genetic disorder characterized by intellectual disabilities and behavioral challenges. Its modulation of glutamatergic transmission has led to investigations into its therapeutic potential in alleviating symptoms associated with this condition.
Used in Neurological and Psychiatric Disorders:
MPEP is used as a candidate for the treatment of various neurological and psychiatric disorders due to its modulation of glutamatergic transmission. Its impact on mGluR5 receptors suggests potential benefits in managing disorders related to glutamate dysregulation.
Check Digit Verification of cas no
The CAS Registry Mumber 775349-54-7 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 7,7,5,3,4 and 9 respectively; the second part has 2 digits, 5 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 775349-54:
(8*7)+(7*7)+(6*5)+(5*3)+(4*4)+(3*9)+(2*5)+(1*4)=207
207 % 10 = 7
So 775349-54-7 is a valid CAS Registry Number.
775349-54-7Relevant academic research and scientific papers
Stereoselective reactions. XXII. Design and synthesis of chiral chelated lithium amides for enantioselective reactions
Shirai,Aoki,Sato,Kim,Murakata,Yasukata,Koga
, p. 690 - 693 (2007/10/02)
Chiral chelated lithium amides ((R))-1a-g) were designed and synthesized in optically pure forms starting from (R)-phenylglycine.
Benzoxazolamines and Benzothiazolamines: Potent, Enantioselective Inhibitors of Leukotriene Biosynthesis with a Novel Mechanism of Action
Lazer, Edward S.,Miao, Clara K.,Wong, Hin-Chor,Sorcek, Ronald,Spero, Denice M.,et al.
, p. 913 - 923 (2007/10/02)
A series of benzoxazolamine and benzothiazolamine analogs that inhibit leukotriene (LT) biosynthesis are described.The initial lead, (S)-N-(benzothiazol-2-yl)phenylalanine ethyl ester (5a), was discovered in a screening program for inhibition of Ca-ionophore-A23187-induced LTB4 release in human polymorphonuclear leukocytes (IC50 0.23 μM).Through structural modification, it was determined that hydrophobic substituents in the 5-position and replacement of the phenyl ring of phenylalanine with a cyclohexyl group greatly enhance potency.Several ester bioisosteres that retain potency and enantiomeric selectivity are described.Lead optimization culminated in (S)-N--5-methyl-2-benzoxazolamine (43b), IC50 0.001 μM.The compounds described are not inhibitors of 5-lipoxygenase but, rather, act at the level of arachidonic acid release.
