775350-72-6

Basic information

• Product Name: (3,4-bis-difluoromethoxy-phenyl)-(4-chloro-phenyl)-methanol
• CAS NO: 775350-72-6
• Molecular Weight: 350.697
• Mol File: 775350-72-6.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (3,4-bis-difluoromethoxy-phenyl)-(4-chloro-phenyl)-methanol(CAS DataBase Reference)
• NIST Chemistry Reference: (3,4-bis-difluoromethoxy-phenyl)-(4-chloro-phenyl)-methanol(775350-72-6)
• EPA Substance Registry System: (3,4-bis-difluoromethoxy-phenyl)-(4-chloro-phenyl)-methanol(775350-72-6)

Safety Data

• Hazardous Substances Data: 775350-72-6(Hazardous Substances Data)

Upstream product

• 127842-54-0 3,4-bis-(difluoromethoxy)-benzaldehyde 
• 873-77-8 (4-chlorphenyl)magnesium bromide 
• 139-85-5 3,4-dihydroxybenzaldehyde 

Downstream Products

• 474499-75-7 4-[2-(3,4-bis-difluoromethoxy-phenyl)-2-(4-chloro-phenyl)-ethyl]-pyridine 

Relevant articles and documents

Discovery of L-791,943: a potent, selective, non emetic and orally active phosphodiesterase-4 inhibitor.

Structure-activity relationship studies directed toward improving the potency and metabolic stability of CDP-840 (3) resulted in the discovery of L-791,943 (11n) as a potent (HWB TNF-alpha = 0.67 microM) and orally active phosphodiesterase type 4 (PDE4) inhibitor. This compound, which bears a stable bis-difluoromethoxy catechol and a pendant hexafluorocarbinol, exhibited a long half-life in rat and in squirrel monkey. It is well tolerated in ferret with an emetic threshold greater than 30 mg/kg (po) and was found to be active in the ovalbumin-induced bronchoconstriction model in guinea pig and in the ascaris-induced bronchoconstriction models in sheep and squirrel monkey.