77544-05-9Relevant academic research and scientific papers
Peptide Cyclols. Crystal Structure and Molecular Conformation of the Oxacyclol derived from L-2-Hydroxyisovaleryl-L-phenylalanyl-L-proline
Lucente, Gino,Pinnen, Francesco,Zanotti, Giancarlo,Cerrini, Silvio,Mazza, Fernando,et al.
, p. 1169 - 1174 (2007/10/02)
Cyclization of L-2-hydroxyisovaleryl-L-phenylalanyl-L-proline p-nitrophenyl ester gives the corresponding tricyclic oxacyclol.The X-ray crystallographic analysis of the oxa-cyclol is reported; crystals are monoclinic, space group P21, a=6.794, b=14.379, c=9.260 Angstroem, β=92.75 deg, Z=2.The final R and RW values are 0.039 and 0.054, respectively, for 1890 independent reflections.The conformation of the rings, the torsion angles, and several conformational details found in the solid state for the oxa-cyclol are discussed and compared with those found for natural ergot alkaloids and related synthetic compounds.A comparison between the conformation of the oxa-cyclol in the crystal with that found in solution by means of 1H n.m.r. spectroscopy, is also reported.
