77548-28-8

Upstream product

• 123-54-6 acetylacetone 
• 122-57-6 1-Phenylbut-1-en-3-one 
• 1896-62-4 (E)-benzalacetone 

Downstream Products

• 50715-82-7 3-methyl-5-phenyl-phenol 

Relevant academic research and scientific papers

Amberlyst-15 catalyzed Michael addition of β-dicarbonyl compounds to the enones and unexpected ring closure products

Conjugate addition reactions of 2,4-pentandione, dibenzoylmethane and ethylacetoacetate to enones have been investigated using Amberlyst-15 or Amberlyst-15-DMAP acetate system as catalysts. When 2,4-pentandione reactions were carried out in the presence o

DBU-Catalyzed Michael Reaction of Enones with 1,3-Diketones and the Subsequent Iodine-Mediated Transformation of the Adducts to Polysubstituted Phenols

An efficient DBU-catalyzed Michael reaction of enones with 1,3-diketones has been developed for the gram-scale preparation of the Michael adducts. It is attractive that most of the adducts can be obtained with high purity through simple filtration. A conv

Iron-catalyzed Michael reactions revisited: A synthetically useful process for the preparation of tri-carbonyl compounds and chiral warfarin

The LBAs (Lewis acid-assisted Br?nsted acid catalysis) is proposed as possible mechanistic process in the simple FeCl3-catalyzed Michael reactions of chalcones with active methylene compounds in organic solvents. And iron salts were found to be effective promoters in the asymmetric Michael addition of 4-hydroxycoumarin to α,β-unsaturated ketone, which resulted in excellent yield and high level of enantioselectivity (up to 91% ee) in the presence of low catalytic amount of iron and simple chiral primary amine.

α-amino acid induced rate acceleration in aqueous biphasic Lewis acid catalyzed Michael addition reactions

It's as easy as ABC: α-Amino acids may become very important tools in the development of economical and environmentally friendly aqueous biphasic catalysis. Alanine accelerated an Yb(OTf)3-catalyzed Michael addition by a factor of 138. The solubilizing and stabilizing properties of alanine allowed the metal catalyst to be "heterogenized" in the aqueous phase and recycled multiple times without appreciable loss of activity.

New Application of 1,4-Dihydropyridine System: Michael Reactions Mediated by 1,4-Dihydropyridine-Enolate Adduct in Micellar Medium

1,4-dihydropyridine-acetophenone enolate adduct, in catalytic amount effects Michael reactions in aqueous cationic micelles of cetyltrimethylammonium bromide. The enolate, generated by dissociation of the adduct abstracts a proton from readily enolizable substrates to bring about the Michael reaction under mild conditions in fair to good yields without side products.

Cu(II)-catalyzed Michael addition of 1,3-dicarbonyl compounds

Copper sulphate pentahydrate catalyses the C-C bond formation via Michael addition of 1,3-dicarbonyl compounds 1 under mild and neutral conditions at ambient temperature and furnishes the products 3 in high yields.

Dual catalysis of the Michael reaction

The Michael reaction, with conjugate bases of β-diketones as donors and with α,β-unsaturated ketones as acceptors, is efficiently catalyzed by a combination of clay-supported nickel bromide (heterogeneous) and ferric chloride (homogeneous).