775538-49-3

Upstream product

• 6297-22-9 4-carbomethoxycyclohexanone 
• 99-96-7 4-hydroxy-benzoic acid 
• 102437-33-2 (1S,3R,4R)-3-Allyl-4-formyl-cyclohexanecarboxylic acid methyl ester 
• 102437-33-2 (1S,3R)-3-Allyl-4-formyl-cyclohexanecarboxylic acid methyl ester 
• 102437-18-3 (1S,3R)-3-Allyl-4-oxo-cyclohexanecarboxylic acid methyl ester 
• 102437-43-4 6-carbomethoxy-trans-2-azadecalin 
• 102437-40-1 (1S,3S,4R)-3-(2-Hydroxy-ethyl)-4-(toluene-4-sulfonyloxymethyl)-cyclohexanecarboxylic acid methyl ester 
• 102437-37-6 (1S,3R,4R)-3-Allyl-4-(toluene-4-sulfonyloxymethyl)-cyclohexanecarboxylic acid methyl ester 
• 102437-30-9 (1S,3R)-3-Allyl-4-[1-methoxy-meth-(Z)-ylidene]-cyclohexanecarboxylic acid methyl ester 
• 102437-36-5 (1S,3R,4R)-3-Allyl-4-hydroxymethyl-cyclohexanecarboxylic acid methyl ester 
• 3618-03-9 methyl 4-hydroxycyclohexanecarboxylate 
• 3685-22-1 4-hydroxycyclohexanecarboxylic acid 

Relevant academic research and scientific papers

General Syntheses of 6- and 7-Carbomethoxy-trans-1-heteradecalins and 6- and 7-Carbomethoxy-trans-2-heteradecalins

Two routes to all of the title compounds in the oxa and aza series have been studied.The most general path, involving a cyclohexene oxide intermediate, was not successful becauase of difficulty in separating regioisomers.Allylation of 4-carbomethoxycyclohexanone (11) followed by reduction produced the required trans-disubstituted allyl alcohols, which were converted to all of the desired 6-carbomethoxy-trans-1-heteradecalins.The allyl ketones were subjected to a homologation-side chain contraction sequence to produce the 6-carbomethoxy-trans-2-heteradecalins.Allylation of 3-carbomethoxycyclohexanone (12) was not regioselective, but all four product isomers were characterized.The desired 5-carbomethoxy-2-allylcyclohexanone isomers (27 and 28) were converted to the 7-carbomethoxy-trans-decalins by similar series of reactions