77556-30-0

Usage

Physical state

Yellow solid

Common uses

Organic synthesis, medicinal chemistry, pharmaceutical drugs, agrochemicals, laboratory reagent

Structural features

Nitro group, bromo-substituted pyrazole ring

Importance

Building block for the synthesis of various organic compounds with diverse applications.

Upstream product

• 76228-53-0 5-nitro-2-(1H-pyrazol-1-yl)pyridine 
• 2075-45-8 4-bromo-1H-pyrazole 
• 4548-45-2 2-chloro-5-nitropyridine 
• 77556-27-5 2-(4-bromo-1H-pyrazol-1-yl)pyridine 

Relevant academic research and scientific papers

Synthesis and pharmacological activity of N-hetaryl-3(5)-nitropyridines

Abstract Previously undescribed 2-, 4or 6-substituted hetaryl-3(5)-nitropyridines were synthesized by the interaction of a number of chlorosubstituted 3(5)-nitropyridines with some diazoles or 3-chloropyridazin-6one. In addition, pyrazolyl-3-nitropyridines were prepared by both the above method and cyclization of hydrazinopyridines, which, in turn, were synthesized by the treatment of chlorosubstituted 3-nitropyridines with hydrazine. It has been shown that these compounds have a moderate antibacterial activity against some pathogenic Gram-positive and Gram-negative bacteria (Staphylococcus aureus and Escherichia coli) and a strong protistocidal effect on protozoa species Colpoda steinii surpassing in this respect clinically used reference drugs.

Hetarylyrazoles. II. Reactions of Pyrazol-1'-ylpyridines

Pyrazol-1'-ylpyridines undergo electrophilic substitution reactions (bromination, chlorination and nitration) preferentially in the pyrazole ring.There is some evidence of the mutual influence of the pyrazole and the pyridine ring on the reactivity of the