775579-10-7

Usage

Uses

Used in Pharmaceutical Industry:
1-(2-METHYLBENZOYL)PIPERAZINE is used as an intermediate in the synthesis of pharmaceuticals for its potential to target various central nervous system disorders. Its unique structure allows for the development of drugs that can address a range of neurological conditions.
Used in Agrochemical Industry:
1-(2-METHYLBENZOYL)PIPERAZINE is used as an intermediate in the synthesis of agrochemicals, contributing to the development of effective and targeted pest control solutions.
Used in Drug Development for Anti-Tumor Properties:
1-(2-METHYLBENZOYL)PIPERAZINE is being studied for its potential anti-tumor properties, with the aim of developing new cancer treatments that can target and inhibit tumor growth.
Used in Organic Synthesis as a Building Block:
Due to its reactive nature and versatility in organic reactions, 1-(2-METHYLBENZOYL)PIPERAZINE is used as a building block in the synthesis of a wide range of chemical compounds, enabling the creation of novel molecules with various applications across different industries.

InChI:InChI=1/C12H16N2O/c1-10-4-2-3-5-11(10)12(15)14-8-6-13-7-9-14/h2-5,13H,6-9H2,1H3

Upstream product

• 110-85-0 piperazine 
• 74738-56-0 4-nitrophenyl 2-methylbenzoate 
• 118-90-1 ortho-methylbenzoic acid 

Relevant academic research and scientific papers

Oxazolo[4,5-b]pyridine-Based Piperazinamides as GSK-3β Inhibitors with Potential for Attenuating Inflammation and Suppression of Pro-Inflammatory Mediators

Recent studies reveal that glycogen synthase kinase-3β (GSK-3β) acts as a pro-inflammatory enzyme, and by inhibiting this kinase, inflammation can be controlled. In this regard, a series of 17 piperazine-linked oxazolo[4,5-b]pyridine-based derivatives was

Effect of o-methyl group on rate, mechanism, and resonance contribution: Aminolysis of Y-substituted phenyl X-substituted 2-methylbenzoates

Second-order rate constants have been determined spectrophotometrically for the reactions of 4-nitrophenyl X-substituted 2-methylbenzoates (2a-e) and Y-substituted phenyl 2-methylbenzoates (3a-e) with alicyclic secondary amines in 80 mol % H2O/20 mol % DMSO at 25.0 ± 0.1 °C. The o-methyl group in the benzoyl moiety of 2a-e retards the reaction rate but does not influence the reaction mechanism. The Hammett plots for the reactions of 2a-e are nonlinear, while the corresponding Yukawa-Tsuno plots are linear with large r values (1.06-1.70). The linear Yukawa-Tsuno plots suggest that stabilization of the ground-state through resonance interaction between the electron donating substituent X and the carbonyl group is responsible for the nonlinear Hammett plots, while the large r values imply that the ground-state resonance interaction is significant. The reactions of 2a-e resulted in smaller ρX values but larger r values than the corresponding reactions of 4-nitrophenyl X-substituted benzoates (1a-e). The small ρX value for the reactions of 2a-e (e.g., ρX = 0.22) is suggested to be responsible for the large r value (e.g., r = 1.70). The reactions of 3a-e with piperidine are proposed to proceed in a stepwise manner with a change in the rate-determining step on the basis of the curved Bronsted-type plot obtained. Microscopic rate constants associated with the reactions of 3a-e are also consistent with the proposed mechanism.