77562-78-8Relevant academic research and scientific papers
Efficient and scalable synthesis of ketones via nucleophilic Grignard addition to nitriles using continuous flow chemistry
Mateos, Carlos,Rincón, Juan A.,Villanueva, José
supporting information, p. 2226 - 2230 (2013/05/08)
In the present Letter we report the development of efficient continuous flow chemistry conditions for the scalable preparation of ketones. This transformation is achieved via nucleophilic addition of Grignard reagents to the corresponding nitriles and imine hydrolysis by means of in-series plug flow reactors.
SPIROPIPERIDINE GLYCINAMIDE DERIVATIVES
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Page/Page column 21, (2008/12/06)
In particular, the present invention is concerned with compounds of the general formula (I) wherein X, Y and R1 to R10 are as described herein. The compounds are V1a receptor antagonists. The invention also relates to the manufacture of compounds of formula I, pharmaceutical compositions containing them and their use for the treatment of anxiety and depressive disorders and other diseases.
