77602-92-7

Usage

Uses

Used in Pharmaceutical Industry:
1-[2-(4-FLUOROPHENOXY)ETHYL]PIPERAZINE is used as an intermediate in the synthesis of various pharmaceuticals for its ability to contribute to the development of new medications.
Used in Agrochemical Industry:
1-[2-(4-FLUOROPHENOXY)ETHYL]PIPERAZINE is used as an intermediate in the production of agrochemicals to aid in the creation of new compounds for agricultural applications.
Used in Research and Development:
1-[2-(4-FLUOROPHENOXY)ETHYL]PIPERAZINE is used as a research compound for the exploration and development of new organic compounds, potentially leading to innovative applications in various fields.
Used in Medicinal Chemistry:
1-[2-(4-FLUOROPHENOXY)ETHYL]PIPERAZINE is used in the field of medicinal chemistry for its potential therapeutic applications, as it may contribute to the discovery of new treatments and therapies.

Upstream product

• 110-85-0 piperazine 
• 332-48-9 2-(4-fluorophenoxy)-ethylbromide 
• 371-41-5 4-Fluorophenol 
• 459-60-9 1-fluoro-4-methoxybenzene 
• 947695-05-8 4-[2-(4-fluorophenoxy)ethyl]piperazine-1-carboxylic acid tert-butyl ester 
• 70931-41-8 4-[2-(4-Fluoro-phenoxy)-ethyl]-piperazine-1-carboxylic acid ethyl ester 

Downstream Products

• 77602-98-3 2-chloro-11-<4-(2-<4-fluorophenoxy>ethyl)piperazino>-10,11-dihydrodibenzothiepin 
• 255847-47-3 1-[(4-cyano-5-hydroxy-5-methyl-4-phenyl)hexyl]-4-[2-(4-fluorophenoxy)ethyl]piperazine 
• 255846-97-0 1-{[4-cyano-5-methyl-4-(3-fluorophenyl)hexyl)}-4-[2-(4-fluorophenoxy)ethyl]piperazine 
• 255846-96-9 1-{[4-cyano-5-methyl-4-(2-fluorophenyl)hexyl]}-4-[2-(4-fluorophenoxy)ethyl]piperazine 
• 255846-94-7 1-{[4-cyano-5-methyl-4-(2-thienyl)hexyl]}-4-[2-(4-fluorophenoxy)ethyl]piperazine 
• 255846-84-5 1-[4-cyano-5-methyl-4-(4-chlorophenyl)hexyl]-4-[2-(4-fluorophenoxy)ethyl]piperazine 
• 1328503-42-9 thiophen-2-yl(4-(2-(4-fluorophenoxy)ethyl)piperazin-1-yl)methanone 
• 1352792-20-1 thiophen-2-yl(4-(2-(4-fluorophenoxy)ethyl)piperazin-1-yl)methanone hydrochloride 

Relevant academic research and scientific papers

Discovery of 1-aryloxyethyl piperazine derivatives as Kv1.5 potassium channel inhibitors (part I)

Kv1.5 potassium channel is an efficacious and safe therapeutic target for the treatment of atrial fibrillation (AF), the most common arrhythmia that threatens human. Herein, by modifying the hit compound 7k from an in-house database, 48 derivatives were synthesized for the assay of their Kv1.5 inhibitory effects by whole cell patch clamp technique. Six compounds which showed better potency than the positive compound dronedarone were selected for the next evaluation of their drug-like properties. Compound 8 exhibited balanced solubility and permeability. It also showed acceptable pharmacodynamics profile with very low acute toxicity. Taking all these data into account, compound 8 can serve as a promising lead for the development of novel therapeutic agent for the treatment of AF.

PIPERAZINE DERIVATIVES

Compounds of general formula (I) in which R1, A1, A2 and R2 have any of the meanings given in the specification, have affinity for sigma receptors and are useful in the treatment of disorders of the central nerv

N,N-SUBSTITUTED CYCLIC AMINE DERIVATIVES

N,N-substituted cyclic amine derivatives represented by general formula (VIII) or pharmacologically acceptable salts thereof: wherein A represents aryl, etc.; E represents -CO- or -CHOH-; G represents oxygen, etc.; J represents optionally substituted aryl; R1 represents lower alkyl, etc.; Alk represents linear or branched lower alkylene; n, v, w, x and y independently represent each 0 or 1; and p represents 2 or 3. These compounds or salts thereof are efficacious in treating diseases against which calcium antagonism is efficacious. These diseases include cerebrovascular disorder at the acute stage, cerebral stroke, cerebral infarction, head injury, cerebral nerve cell death, Alzheimer's disease, Parkinson's disease, amyotrophic lateral sclerosis, Huntington's disease, brain circulatory disturbance, brain function disturbance, pain, convulsion, schizophrenia, hemicrania, epilepsy, circular psychosis, nerve degeneration diseases, brain ischemia, AIDS, complex dementia, edema, anxiety and diabetic nephropathy.