776239-07-7

Usage

Uses

Used in Medicinal Chemistry:
2-Bromo-5-fluorophenylhydrazine HCl is utilized as a key intermediate in the synthesis of pharmaceutical drugs, contributing to the development of new medications with potential therapeutic benefits.
Used in Agrochemicals:
In the agrochemical industry, 2-Bromo-5-fluorophenylhydrazine HCl serves as a crucial component in the production of herbicides and insecticides, helping to control and manage pests and weeds in agricultural settings.
Used in Cancer Research:
2-Bromo-5-fluorophenylhydrazine HCl is investigated for its potential to inhibit the growth of cancer cells, making it a subject of interest in cancer research. Its ability to target and affect cancerous cells positions it as a promising candidate for further exploration in oncology.
These applications highlight the diverse utility of 2-Bromo-5-fluorophenylhydrazine HCl, underscoring its importance in the advancement of pharmaceuticals, agrochemicals, and cancer treatments.

Upstream product

• 60481-35-8 1-(2-bromo-5-fluorophenyl)hydrazine hydrochloride 
• 1003-99-2 2-bromo-5-fluoroaniline 

Downstream Products

• 936363-91-6 1-(2-bromo-5-fluorophenyl)-5-methyl-1H-1,2,4-triazole 

Relevant academic research and scientific papers

Chiral Aniline Synthesis via Stereospecific C(sp3)-C(sp2) Coupling of Boronic Esters with Aryl Hydrazines

An enantiospecific coupling between alkylboronic esters and lithiated aryl hydrazines is described. The reaction proceeds under transition-metal-free conditions and is promoted by acylation of a hydrazinyl arylboronate complex, which triggers a N-N bond cleavage with concomitant 1,2-metalate rearrangement. Judicious choice of the acylating agent enabled the synthesis of ortho- and para-substituted anilines with essentially complete enantiospecificity from a wide range of boronic ester substrates.

CRYSTALLINE FORMS OF 4, 4'- [4-FLUORO-7-( ETHYNYL)-2-METHYL-1H-INDOLE-1,3-DIYL] DIBUTANOIC ACID, 4,4'-[2-METHYL-7-( ETHYNYL)-1H-INDOLE-1, 3-DIYL] DIBUTANOIC ACID, AND 4,4'-[4-FLUORO-2-METHYL-7- ( ETHYNYL)-1H-INDOLE-1, 3-DIYL] DIBUTANOIC ACID

The present invention provides type C crystal of compound I, type B crystal of compound II, or type C crystal of compound III set forth in this specification.

ETHYNYLINDOLE COMPOUNDS

As a compound having a potent oral activity and a long-lasting cysLT1/cysLT2 receptor antagonistic activity, the compound of the formula (I): which exhibits potent antagonistic activity against the cysLT1/cysLT2 /sub

1, 5-DIHYDRO-PYRAZOLO (3, 4-D) PYRIMIDIN-4-ONE DERIVATIVES AND THEIR USE AS PDE9A MODULATORS FOR THE TEATMENT OF CNS DISORDERS

The invention relates to novel substituted pyrazolopyrimidines. Chemically, the compounds are characterised by general Formula (I): with R1 being phenyl or pyridyl, any of which is substituted with 1 to 4, preferably 1 to 3 substituents X; X in

HIV integrase inhibitors

The invention encompasses a series bicyclic pyrimidinone compounds of Formula I which inhibit HIV integrase and prevent viral integration into human DNA. This action makes the compounds useful for treating HIV infection and AIDS. The invention also encompasses pharmaceutical compositions and methods for treating those infected with HIV.