776302-75-1

Upstream product

• 16629-19-9 thiophene-2-sulfonyl chloride 
• 776302-70-6 methanesulfonic acid 3-(2-{[2-(3-amino-phenyl)-2-hydroxy-ethyl]-tert-butoxycarbonyl-amino}-propyl)-1H-indol-7-yl ester 
• 2227-64-7 3'-nitro-2-bromoacetophenone 
• 776302-72-8 methanesulfonic acid 3-(2-{tert-butoxycarbonyl-[2-hydroxy-2-(3-nitro-phenyl)-ethyl]-amino}-propyl)-1H-indol-7-yl ester 
• 776302-71-7 Methanesulfonic acid 3-{(R)-2-[(R)-2-hydroxy-2-(3-nitro-phenyl)-ethylamino]-propyl}-1H-indol-7-yl ester 
• 193761-55-6 (R)-2-bromo-1-(3-nitrophenyl)ethan-1-ol 
• 129215-12-9 (R)-2-(3-nitrophenyl)oxirane 

Relevant academic research and scientific papers

Tryptamine-based human β3-adrenergic receptor agonists. Part 2: SAR of the methylene derivatives

In an effort to reduce the cost of production, we conducted further optimization of tryptamine-based β3-adrenergic receptor (AR) agonists. Optimization of the left-hand side aryl moiety led to the identification of a series of potent β3/s