776305-24-9Relevant academic research and scientific papers
Design, synthesis, and biological evaluation of peptidomimetic inhibitors of factor XIa as novel anticoagulants
Lin, Jian,Deng, Hongfeng,Jin, Lei,Pandey, Pramod,Quinn, Jesse,Cantin, Susan,Rynkiewicz, Michael J.,Gorga, Joan C.,Bibbins, Frank,Celatka, Cassandra A.,Nagafuji, Pamela,Bannister, Thomas D.,Meyers, Harold V.,Babine, Robert E.,Hayward, Neil J.,Weaver, David,Benjamin, Howard,Stassen, Frans,Abdel-Meguid, Sherin S.,Strickler, James E.
, p. 7781 - 7791 (2007/10/03)
Human coagulation factor XIa (FXIa), a serine protease activated by site-specific cleavage of factor XI by thrombin, FXIIa, or autoactivation, is a critical enzyme in the amplification phase of the coagulation cascade. To investigate the potential of FXIa
