776312-23-3

Usage

Thiophene derivative

A compound based on the thiophene ring structure, which is a five-membered heterocyclic ring system containing one sulfur atom and four carbon atoms.

Carboxylic acid group

A functional group consisting of a carbonyl group (C=O) and a hydroxyl group (OH) attached to the same carbon atom, represented as -COOH.

Hydroxymethylphenyl group

A phenyl ring (a six-membered carbon ring with delocalized electrons) with a hydroxymethyl group (-CH2OH) attached to it.

Unique structure

The combination of the thiophene ring, carboxylic acid group, and hydroxymethylphenyl group gives 2-(3-Hydroxymethylphenyl)thiophene-3-carboxylic acid its distinct chemical properties.

Potential biological activities

The compound may exhibit biological effects or interactions with biological systems, which could be harnessed for therapeutic purposes.

Applications in organic chemistry and pharmaceuticals

Due to its unique structure and potential biological activities, 2-(3-Hydroxymethylphenyl)thiophene-3-carboxylic acid can be used in the synthesis of novel drugs and as a starting material for developing new chemical compounds.

Ongoing research and experimentation

The specific properties and uses of 2-(3-Hydroxymethylphenyl)thiophene-3-carboxylic acid are still being explored, and further studies are needed to fully understand its potential applications and effects.

Upstream product

• 4701-17-1 5-bromo-2-thiophencarboxaldehyde 
• 59016-93-2 p-hydroxymethylphenylboronic acid 
• 1313398-19-4 (4-(5-(1,3-dioxolan-2-yl)thiophen-2-yl)phenyl)methanol 
• 52157-62-7 2-(5-bromothiophen-2-yl)-1,3-dioxolane 

Downstream Products

• 1313397-23-7 4-(5-((5-oxo-2-thioxoimidazolidin-4-ylidene)methyl)thiophen-2-yl)benzyl acetate 
• 776312-32-4 5-(4-chloromethylphenyl)thiophene-2-carbaldehyde 

Relevant academic research and scientific papers

Exploration of a series of 5-arylidene-2-thioxoimidazolidin-4-ones as inhibitors of the cytolytic protein perforin

A series of novel 5-arylidene-2-thioxoimidazolidin-4-ones were investigated as inhibitors of the lymphocyte-expressed pore-forming protein perforin. Structure-activity relationships were explored through variation of an isoindolinone or 3,4-dihydroisoquinolinone subunit on a fixed 2-thioxoimidazolidin-4-one/thiophene core. The ability of the resulting compounds to inhibit the lytic activity of both isolated perforin protein and perforin delivered in situ by natural killer cells was determined. A number of compounds showed excellent activity at concentrations that were nontoxic to the killer cells, and several were a significant improvement on previous classes of inhibitors, being substantially more potent and soluble. Representative examples showed rapid and reversible binding to immobilized mouse perforin at low concentrations (≤2.5 μM) by surface plasmon resonance and prevented formation of perforin pores in target cells despite effective target cell engagement, as determined by calcium influx studies. Mouse PK studies of two analogues showed T1/2 values of 1.1-1.2 h (dose of 5 mg/kg iv) and MTDs of 60-80 mg/kg (ip).

COMPOUNDS, PREPARATIONS AND USES THEREOF

The present invention provides novel compounds of the Formula (I), pharmaceutical compositions comprising such compounds and methods for using such compounds as agents or drugs for inhibiting perforin activity and for treating a subject at risk of or susc

HETEROAROMATIC PENTACYCLIC COMPOUND AND MEDICINAL USE THEREOF

A 5-membered heteroaromatic ring compound represented by the formula [I] wherein V is CH or N; W is S or O; R1 and R2 are each H etc.; X is -N(R4)-, -O-, -S-, -SO2-N(R5)-, -CO-N(R7)- etc.;