776317-99-8

Basic information

• Product Name: 3β-acetoxy-21-p-toluenesulfonyloxymethylpregn-5-ene-20β-ol
• Synonyms: 3β-acetoxy-21-p-toluenesulfonyloxymethylpregn-5-ene-20β-ol
• CAS NO: 776317-99-8
• Molecular Weight: 544.753
• Mol File: 776317-99-8.mol

Chemical Properties

• CAS DataBase Reference: 3β-acetoxy-21-p-toluenesulfonyloxymethylpregn-5-ene-20β-ol(CAS DataBase Reference)
• NIST Chemistry Reference: 3β-acetoxy-21-p-toluenesulfonyloxymethylpregn-5-ene-20β-ol(776317-99-8)
• EPA Substance Registry System: 3β-acetoxy-21-p-toluenesulfonyloxymethylpregn-5-ene-20β-ol(776317-99-8)

Safety Data

• Hazardous Substances Data: 776317-99-8(Hazardous Substances Data)

Downstream Products

• 776318-00-4 3β-acetoxy-21-p-toluenesulfonyloxymethylpregn-5-ene-20β-N-phenylurethane 

Relevant articles and documents

Neighboring group participation: Part 15. Stereoselective synthesis of some steroidal tetrahydrooxazin-2-ones, as novel presumed inhibitors of human 5α-reductase

During the alkaline methanolysis of 3β-acetoxy-21-chloromethyl-pregn- 5-ene-20β-N-phenylurethane, and its p-substituted phenyl derivatives, cyclization occurs, in the course of which 17β-[3-(N-phenyl) tetrahydrooxazin-2-on-6-yl]androst-5-en-3β-ol and its p-substituted phenyl derivatives are formed. The cyclization takes place with (N--6) neighboring group participation. Oppenauer oxidation of the 3β-hydroxy-exo- heterocyclic steroids yielded the corresponding Δ4-3- ketosteroids. The structures of the new compounds were proved by IR, 1H and 13C NMR spectroscopy, using up-to-date measuring techniques such as 2D-COSY, HMQC, and HMBC. The inhibitory effects (CI 50) of the Δ4-3-ketosteroids on 5α-reductase were studied.