776322-55-5Relevant academic research and scientific papers
The novel benzopyran class of selective cyclooxygenase-2 inhibitors. Part 2: The second clinical candidate having a shorter and favorable human half-life
Wang, Jane L.,Limburg, David,Graneto, Matthew J.,Springer, John,Hamper, Joseph Rogier Bruce,Liao, Subo,Pawlitz, Jennifer L.,Kurumbail, Ravi G.,Maziasz, Timothy,Talley, John J.,Kiefer, James R.,Carter, Jeffery
scheme or table, p. 7159 - 7163 (2011/01/03)
In this Letter, we provide the structure-activity relationships, optimization of design, testing criteria, and human half-life data for a series of selective COX-2 inhibitors. During the course of our structure-based drug design efforts, we discovered two
