77638-65-4

Upstream product

• 77638-63-2 5-methoxy-11-methyl-3,4-dihydro-6H-pyrido<4,3-b>carbazole 
• 79204-77-6 methyl (Z)-4-methyl-1-oxo-1,2,3,4-tetrahydrocarbazol-2-ylideneacetate 
• 79204-76-5 [4-Methyl-1-oxo-1,3,4,9-tetrahydro-carbazol-(2E)-ylidene]-acetic acid methyl ester 
• 77638-61-0 2-(2-formamidoethyl)-1-methoxy-4-methylcarbazole 
• 77638-58-5 1-hydroxy-4-methylcarbazole-2-acetamide 
• 77638-60-9 1-methoxy-4-methylcarbazole-2-acetonitrile 
• 77638-66-5 5-methyl-2,3-dihydrofuro<2,3-a>carbazol-2-one 

Relevant academic research and scientific papers

REACTIONS AND SYNTHETIC APPLICATIONS OF β-KETO SULFOXIDES IX. SYNTHESIS OF 5-METHYLTHIO AND 5-METHOXY ANALOGS OF ELLIPTICINE

A β-keto sulfoxide (9) derived from ethyl indolebutyrate (8) and FAMSO was cyclized to a 2-keto-1,2,3,4-tetrahydrocarbazole derivative (10).After introduction of an acetic ester at the carbonyl group to give 11, its aromatization gave a 1-methylthiocarbazole (12), followed by construction of a pyridine ring to yield efficiently 5-methylthioellipticine (6).Compound 11 was quite easily hydrolyzed to a 1-keto derivative (18), which was aromatized and then converted to 5-methoxyellipticine (7).