77646-05-0

Upstream product

• 77606-94-1 2-(4-chlorophenyl)-1,2,3,4-tetrahydro[1]benzothiopyrano[4,3-c]pyrazol-3-one-5-oxide 
• 1073-69-4 N-4-chlorophenylhydrazine 
• 77617-75-5 2-(p-chlorophenyl)-1,2,3,4-tetrahydro<1>benzothiopyrano<4,3-c>pyrazol-3-one 
• 6125-48-0 methyl 4-oxothiochromane-3-carboxylate 

Relevant academic research and scientific papers

Novel Immunosupperessive Agents. Potent Immunological Activity of Some Benzothiopyranopyrazol-3-ones

A unique class of immunosuppressant agents has been found by the use of a mouse model of immunity.A number of benzothiopyranopyrazol-3-ones are potent inhibitors of both the humoral and cellular immune response developed in mice in response to ELs

[1]Benzothiopyrano[4,3-c]pyrazoles as immunoregulatory agents

1,2,3,4-Tetrahydrobenzothiopyrano[4,3-c]pyrazol-3-ones and 2,3-dihydro[1]benzothiopyrano[4,3-c]pyrazol-3-ones, of respective structure I and II, STR1 wherein n is an integer of value from 0 to 2; R is phenyl; phenyl monosubstituted with chloro, bromo, fluoro, methyl, methoxy, nitro or trifluoromethyl; or phenyl disubstituted with chloro; and X is hydrogen or chloro; are described. These novel compounds are immunoregulators which, through suppression of the immune response in mammals, are useful in inhibiting rejection of organ transplants, as well as in the therapy of auto-immune diseases.