77655-48-2Relevant academic research and scientific papers
SINTESI ED ATTIVITA ANTIBATTERICA IN VITRO DI N-METILNITRONI E NITROVINILI DERIVATI DA ALCUNE 2-CLOROINDOL-3-CARBOSSIALDEIDI N-SOSTITUITE
Gatti, R.,Cavrini, V.,Roveri, P.,Bianucci, F.,Legnani, P.
, p. 102 - 108 (2007/10/02)
N-methylnitrones and nitrovinyl derivatives from 1-substituted-2-chloroindole-3-carboxaldehydes were synthesized and evaluated for their in vitro antibacterial activity.Some nitrovinyl derivatives displayed good in vitro activity against Gram-positive bacteria; the compound (II e), 1-(o-chlorobenzyl)-2-chloro-3-(2-nitroethenyl)indole, was more active than nitrofurantoin against Staphylococcus aureus and Streptococcus pyogenes.Some structure-activity relationships are discussed.
