77668-01-0Relevant academic research and scientific papers
Pyrazolo[1,5- a ]-1,3,5-triazine C-nucleoside as deoxyadenosine analogue: Synthesis, pairing, and resistance to hydrolysis
Lefoix, Myriam,Mathis, Gérald,Kleinmann, Tirtsa,Truffert, Jean-Christophe,Asseline, Ulysse
, p. 3221 - 3227 (2014/05/06)
The synthesis of a pyrazolo[1,5-a]-1,3,5-triazine C-nucleoside (dA PT), designed to form two hydrogen bonds with a complementary dT residue, is reported. Oligonucleotides including this dA nucleoside analogue possess base-pairing properties similar to those of the parent oligonucleotide. This dA nucleoside analogue is more resistant to acid-catalyzed hydrolysis than dA.
SULFONAMIDE, SULFAMATE, AND SULFAMOTHIOATE DERIVATIVES
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Page/Page column 46, (2012/04/05)
The disclosure provides biologically active compounds of formula (I): and pharmaceutically acceptable salts thereof, compositions containing these compounds, and methods of using these compounds in a variety applications, such as treatment of diseases or disorders associated with E1 type activating enzymes, and with Nedd8 activating enzyme (NAE) in particular.
Angiotensin II receptor blocking 2,3-substituted pyrazolo[1,5-a]-1,3,5-triazin-4(3H)-ones
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, (2008/06/13)
The invention provides novel 2,3-substituted pyrazolo[1,5-a]-1,3,5-triazin-4(3H)-ones having the formula: STR1 wherein R 1, R 2 and R 3 are described in the specification which have activity as angiotensin II (AII) antagonists.
Nucleosides. 117. Synthesis of 4-Oxo-8-(β-D-ribofuranosyl)-3H-pyrazolo-1,3,5-triazine (OPTR) via 3-Amino-2N-carbamoyl-4-(β-D-ribofuranosyl)pyrazole (ACPR) Derivatives
Chu, C. K.,Watanabe, K. A.,Fox, J. J.
, p. 1435 - 1439 (2007/10/02)
Reaction of 2-formyl-2-(2,3-O-isoprpylidene-5-O-trityl-D-ribofuranosyl)acetonotrile (VII) with semicarbazide hydrochloride followed by sodium ethoxide treatment afforded α,β-mixture of 3-amino-2N-carbamoyl-4-(2,3-O-isopropylidene-5-O-trityl-D-ribofuranosyl)pyrazole (IX).Conversion of IX to 4-oxo-8-(2,3-O-isopropylidene-5-O-trityl-D-ribofuranosyl)-3H-pyrazolo-1,3,5-triazine (XIII) was achieved by treatment of IX with ethylorthoformate.The β-isomer IXb gave only β-isomer XIIIb, and the α-isomer was converted exclusively into the α-isomer XIIIa.Upon deprotection with 3percent n-butanolic hydrogen chloride, both IXa and IXb gave the same mixture of the α- and β-isomers of 3-amino-2N-carbamoyl-4-(D-ribosyl)pyrazole, which were separated by chromatography. The syntheses of the hitherto unknown compounds, 3-amino-2N-carbamoylpyrazole (IVa) and its 4-methyl analog (IVb) are also reported.Experimental details of the synthesis of 3-amino-4-(2,3-O-isopropylidene-5-O-trityl-β-D-ribofuranosyl)pyrazole (XIIb), an important intermediate for "purine-like" C-nucleosides, are also described.
