77673-51-9Relevant academic research and scientific papers
Synthesis of an Air-Stable Pd(0) Catalyst Bearing Donor and Acceptor Phosphine Ligands
Kanbara, Takaki,Kuwabara, Junpei,Sato, Ryota
, (2020)
We synthesized a new Pd(0) complex bearing π-acceptor ligands and a σ-donor ligand and confirmed that it exhibits high air stability and catalytic activity in direct arylation reactions. Moreover, stoichiometric reactions of the complex revealed that the σ-donor ligand does not dissociate from the Pd center.
Synthesis and Structural Characterization of Ricin Inhibitors Targeting Ribosome Binding Using Fragment-Based Methods and Structure-Based Design
Augeri, David,Cao, Bin,Harijan, Rajesh K.,Kahn, Jennifer N.,Li, Xiao-Ping,Pierce, Michael,Roberge, Jacques Y.,Tsymbal, Anastasiia M.,Tumer, Nilgun E.
, p. 15334 - 15348 (2021/11/01)
Ricin toxin A subunit (RTA) is the catalytic subunit of ricin, which depurinates an adenine from the sarcin/ricin loop in eukaryotic ribosomes. There are no approved inhibitors against ricin. We used a new strategy to disrupt RTA-ribosome interactions by
Air-stable Pd(0) catalyst bearing dual phosphine ligands: a detailed evaluation of air stability and catalytic property in cross-coupling reactions
Sato, Ryota,Kanbara, Takaki,Kuwabara, Junpei
, p. 12814 - 12819 (2020/10/02)
We have synthesised an air-stable Pd(0) catalyst bearing donor and acceptor phosphine ligands (Complex1). This study revealed the long-term air stability and catalytic property of Complex1as a catalyst for cross-coupling reactions, where it was stable in air for eight months. DFT calculations revealed that the acceptor ligands in Complex1decreased the HOMO energy level, which provided the observed air stability. Complex1successfully served as a catalyst for direct C-H arylation reactions and Suzuki-Miyaura cross-coupling reactions, and catalysed the reaction of a relatively inactive substrate, 2-chrolopyridine, which could not be achieved by conventional, air-stable Pd(0) catalysts. Isolating the intermediates of the coupling reactions revealed that each intermediate possessed the donor ligand (PCy3), which was determined to be responsible for imparting the high catalytic activity exhibited by Complex1.
Direct C-H arylation of thiophenes at low catalyst loading of a phosphine-free bis(alkoxo)palladium complex
Li, Yabo,Wang, Jingran,Huang, Mengmeng,Wang, Zhiwei,Wu, Yusheng,Wu, Yangjie
, p. 2890 - 2897 (2014/05/06)
An efficient phosphine-free direct C-H arylation of thiophenes at the α-position has been developed at low catalyst loading of bis(alkoxo)palladium complex (Cat.I, 0.1-0.2 mol %). The developed synthetic method can be applied to the synthesis of α-aryl/heteroaryl thiophenes from aryl or heteroaryl bromides in good to excellent yields and is compatible with the substrates bearing electron-donating or electron-withdrawing groups. The reactivities of the 2- and 5-positions of thiophenes are equivalent and not dependent on steric hindrance under optimal conditions. This condition can also be applied to other heterocyclic moieties such as benzothiophene, benzofuran, and pyrrole with high conversion yields.
