77694-60-1

Basic information

• Product Name: 3-(anilinomethyl)thiochromate 1,1-dioxide
• Synonyms: 3-(anilinomethyl)thiochromate 1,1-dioxide
• CAS NO: 77694-60-1
• Molecular Weight: 299.35
• Mol File: 77694-60-1.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 3-(anilinomethyl)thiochromate 1,1-dioxide(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(anilinomethyl)thiochromate 1,1-dioxide(77694-60-1)
• EPA Substance Registry System: 3-(anilinomethyl)thiochromate 1,1-dioxide(77694-60-1)

Safety Data

• Hazardous Substances Data: 77694-60-1(Hazardous Substances Data)

Upstream product

• 77694-48-5 3-(chloromethyl)thiochromone 1,1-dioxide 
• 62-53-3 aniline 
• 491-39-4 thiochromen-4-one 
• 22810-27-1 1-thiochromone 1,1-dioxide 

Relevant articles and documents

Synthesis and Antitumor Activity of a Series of Sulfone Analogues of 1,4-Naphthoquinone

A series of novel subsituted thiochromones and thiochroman-4-ones was synthesized.Compounds were designed as anlogues of naphthoquinone and as potential "bioreductive alkylating agents" and were tested for antitumor activity.The lead compound, 3-(chloromethyl)thiochromone 1,1-dioxide (4), inhibited Ehrlich ascites tumor growth by 100percent in CF1 male mice at 10 (mg/kg) day ip.Similarly, 18 of the 29 related compounds demonstrated good activity in this tumor screen.Few definitive structure-activity correlations were evident regarding the nature of the 3-substituent.How ever, the 2,3 double bond and a sulfone or sulfoxide were required for activity.Four of the compounds synthesized showed marginal but significant activity against P-388 lymphocytic leukemia.