777-33-3

Usage

Uses

Useful in the synthesis of 2-amino-6,7-dihydroxy-1,2,3,4-tetrahydronaphthalene, a potent dopamine agonist. Used in the synthesis of sweetening agents, such as N-trifluoroacetyl-L-aspartic acid α-amides and α-anilides.

InChI:InChI=1/C6H4F3NO4/c7-6(8,9)5(13)10-2-1-3(11)14-4(2)12/h2H,1H2,(H,10,13)/t2-/m0/s1

Upstream product

• 56-84-8 L-Aspartic acid 
• 76-05-1 trifluoroacetic acid 
• 407-25-0 trifluoroacetic anhydride 

Downstream Products

• 41594-85-8 (S)-N-(4-Carbamoyl-phenyl)-3-(2,2,2-trifluoro-acetylamino)-succinamic acid 
• 41567-20-8 N-trifluoroacetyl-L-aspartyl-L-phenylalanine 
• 41567-04-8 (S)-N-(4-Hydroxy-phenyl)-3-(2,2,2-trifluoro-acetylamino)-succinamic acid 
• 41567-05-9 trifluoroacetyl-α-L-aspartyl-p-toluidide 
• 41696-59-7 N¹-phenyl-N²-trifluoroacetyl-L-isoasparagine 
• 48193-99-3 trifluoroacetyl-α-L-aspartyl-o-chloroanilide 
• 48213-99-6 4-[(S)-3-Carboxy-2-(2,2,2-trifluoro-acetylamino)-propionylamino]-benzoic acid ethyl ester 

Relevant academic research and scientific papers

NEW COMPOUND USEFUL IN THE MANUFACTURE OF MEDICAMENTS

The present invention relates to a compound of formula (I) as defined in the description and in the claims. The compound of formula (I) can be used in the manufacture of medicaments.

GRANZYME B DIRECTED IMAGING AND THERAPY

Provided herein are heterocyclic compounds useful for imaging Granzyme B. Methods of imaging Granzyme B, combination therapies, and kits comprising the Granzyme B imaging agents are also provided.

Regioselective opening of unsymmetrical cyclic anhydrides: Synthesis of N-glycosylated isoasparagine and isoglutamine conjugates

N-Glycopeptide mimetic with N-glycosylated isoasparagine and isoglutamine conjugates were synthesized by regioselective opening of unsymmetrical cyclic anhydride derivatives of l-aspartic acid and l-glutamic acid, using per-O-acetylated β-d-glycopyranosyl amine. The α-chloro derivative gave a mixture of asparagine and isoasparagine linked glycoconjugates, whereas the trifluoroacetamide derivatives gave predominantly the isoasparagine and isoglutamine linked glycoconjugates as the product. The X-ray crystal structure of the α-chloro isoasparagine linked glycoconjugate showed unique pattern of hydrogen bonding. This journal is the Partner Organisations 2014.

Synthesis of (2S)-O-phosphohomoserine and its C-2 deuteriated and C-3 chirally deuteriated isotopomers: Probes for the pyridoxal phosphate-dependent threonine synthase reaction

A short efficient synthesis of the threonine synthase substrate (2S)-O-phosphohomoserine and its C-2 deuteriated and C-3 chirally deuteriated isotopomers is described. The synthetic route also provides access to (2S)-homoserine and its C-2 deuteriated and C-3 chirally deuteriated isotopomers in high yield. Preliminary deuterium isotope effect determinations performed using the deuteriated (2S)-O-phosphohomoserines and threonine synthase from E. coli indicate that the removal of protons from both C-2 and C-3 is kinetically important.

Synthesis of L-Glutamic Acid Labelled Stereospecifically at C-3 with Deuterium and Non-stereospecifically at C-4 with Tritium

(2S,3S)-1>-, (2S,3R)-2>-, (2S,3S,4RS)-1,4-3H1>-, and (2S,3R,4RS)-2,4-3H1>-Glutamic acid have been synthesised from the corresponding labelled aspartic acids.The route involves a step where Wolff rearrangement occurs with retention of stereochemistry at a primary migrating chiral centre.The stereochemistry at C-3 of the glutamic acids has been verified by degradation to the corresponding stereospecifically labelled 1>succinic acids.