777-33-3

Usage

Uses

Useful in the synthesis of 2-amino-6,7-dihydroxy-1,2,3,4-tetrahydronaphthalene, a potent dopamine agonist. Used in the synthesis of sweetening agents, such as N-trifluoroacetyl-L-aspartic acid α-amides and α-anilides.

InChI:InChI=1/C6H4F3NO4/c7-6(8,9)5(13)10-2-1-3(11)14-4(2)12/h2H,1H2,(H,10,13)/t2-/m0/s1

Upstream product

• 56-84-8 L-Aspartic acid 
• 407-25-0 trifluoroacetic anhydride 
• 76-05-1 trifluoroacetic acid 

Downstream Products

• 41594-85-8 (S)-N-(4-Carbamoyl-phenyl)-3-(2,2,2-trifluoro-acetylamino)-succinamic acid 
• 41567-20-8 N-trifluoroacetyl-L-aspartyl-L-phenylalanine 
• 41567-04-8 (S)-N-(4-Hydroxy-phenyl)-3-(2,2,2-trifluoro-acetylamino)-succinamic acid 
• 41567-05-9 trifluoroacetyl-α-L-aspartyl-p-toluidide 
• 41696-59-7 N¹-phenyl-N²-trifluoroacetyl-L-isoasparagine 
• 48193-99-3 trifluoroacetyl-α-L-aspartyl-o-chloroanilide 
• 48213-99-6 4-[(S)-3-Carboxy-2-(2,2,2-trifluoro-acetylamino)-propionylamino]-benzoic acid ethyl ester 
• 92398-78-2 trifluoroacetyl-α-L-aspartyl-2,3-dinitroanilide 
• 92398-81-7 trifluoroacetyl-α-L-aspartyl-3-methyl-4-nitroanilide 
• 92398-77-1 trifluoroacetyl-α-L-aspartyl-3,4-dinitroanilide 

Relevant academic research and scientific papers

GRANZYME B DIRECTED IMAGING AND THERAPY

Provided herein are heterocyclic compounds useful for imaging Granzyme B. Methods of imaging Granzyme B, combination therapies, and kits comprising the Granzyme B imaging agents are also provided.

NEW COMPOUND USEFUL IN THE MANUFACTURE OF MEDICAMENTS

The present invention relates to a compound of formula (I) as defined in the description and in the claims. The compound of formula (I) can be used in the manufacture of medicaments.

Regioselective opening of unsymmetrical cyclic anhydrides: Synthesis of N-glycosylated isoasparagine and isoglutamine conjugates

N-Glycopeptide mimetic with N-glycosylated isoasparagine and isoglutamine conjugates were synthesized by regioselective opening of unsymmetrical cyclic anhydride derivatives of l-aspartic acid and l-glutamic acid, using per-O-acetylated β-d-glycopyranosyl amine. The α-chloro derivative gave a mixture of asparagine and isoasparagine linked glycoconjugates, whereas the trifluoroacetamide derivatives gave predominantly the isoasparagine and isoglutamine linked glycoconjugates as the product. The X-ray crystal structure of the α-chloro isoasparagine linked glycoconjugate showed unique pattern of hydrogen bonding. This journal is the Partner Organisations 2014.

Synthesis of (2S)-O-phosphohomoserine and its C-2 deuteriated and C-3 chirally deuteriated isotopomers: Probes for the pyridoxal phosphate-dependent threonine synthase reaction

A short efficient synthesis of the threonine synthase substrate (2S)-O-phosphohomoserine and its C-2 deuteriated and C-3 chirally deuteriated isotopomers is described. The synthetic route also provides access to (2S)-homoserine and its C-2 deuteriated and C-3 chirally deuteriated isotopomers in high yield. Preliminary deuterium isotope effect determinations performed using the deuteriated (2S)-O-phosphohomoserines and threonine synthase from E. coli indicate that the removal of protons from both C-2 and C-3 is kinetically important.

Synthesis of L-Glutamic Acid Labelled Stereospecifically at C-3 with Deuterium and Non-stereospecifically at C-4 with Tritium

(2S,3S)-1>-, (2S,3R)-2>-, (2S,3S,4RS)-1,4-3H1>-, and (2S,3R,4RS)-2,4-3H1>-Glutamic acid have been synthesised from the corresponding labelled aspartic acids.The route involves a step where Wolff rearrangement occurs with retention of stereochemistry at a primary migrating chiral centre.The stereochemistry at C-3 of the glutamic acids has been verified by degradation to the corresponding stereospecifically labelled 1>succinic acids.