777089-38-0

Upstream product

• 777089-37-9 N-[((5S)-3-{4-[(1α,5α,6β)-3-azabicyclo[3.1.0]hex-6-yl]-3-fluorophenyl}-2-oxo-1,3-oxazolidin-5-yl)methyl]acetamide 
• 19810-31-2 Benzyloxyacetyl chloride 
• 183905-31-9 N-[(2S)-2-acetoxy-3-chloropropyl]acetamide 

Downstream Products

• 777089-75-5 N-{(S)-3-[4-((1S,5R,6S)-3-Cyano-3-aza-bicyclo[3.1.0]hex-6-yl)-3-fluoro-phenyl]-2-oxo-oxazolidin-5-ylmethyl}-acetamide 
• 777088-62-7 N-((S)-3-{3-Fluoro-4-[(1S,5R,6S)-3-(1H-tetrazol-5-yl)-3-aza-bicyclo[3.1.0]hex-6-yl]-phenyl}-2-oxo-oxazolidin-5-ylmethyl)-acetamide 

Relevant academic research and scientific papers

Conformational constraint in oxazolidinone antibacterials. Part 2: Synthesis and structure-activity studies of oxa-, aza-, and thiabicyclo[3.1.0] hexylphenyl oxazolidinones

A new class of oxazolidinone antibacterials incorporating oxygen-, nitrogen-, or sulfur-containing heterobicyclic C-rings is described. The in vitro potency and in vivo efficacy of these conformationally constrained oxazolidinone analogs are discussed.