77712-32-4Relevant articles and documents
Two-step synthesis of 2-(9-Hydroxynonyl)-5,6-dimethoxy-3-methyl-1,4- benzoquinone
Wang, Jin,Hu, Xiao,Yang, Jian
, p. 2371 - 2375 (2014)
2-(9-Hydroxynonyl)-5,6-dimethoxy-3-methyl-1,4-benzoquinone was readily synthesized from commercially available 3,4,5-trimethoxytoluene in two steps. First, 2,3-dimethoxy-5-methyl-1,4-benzoquinone (coenzyme Q0) was obtained in one step by treatment of 3,4,5-trimethoxytoluene with hydrogen peroxide under metal-free conditions, followed by free-radical alkylation with 10-hydroxydecanoic acid in the presence of potassium peroxodisulfate and silver nitrate in a mixed solvent (MeCN-H2O, 1:1) to afford the title compound in good yields (60%, based on coenzyme Q0). Georg Thieme Verlag Stuttgart. New York.
Synthesis and antioxidant activities of Coenzyme Q analogues
Wang, Jin,Li, Shuo,Yang, Tao,Yang, Jian
, p. 710 - 713 (2015/02/19)
A series of 2,3-dimethoxy-5-methyl-1,4-benzoquinones (Coenzyme Q) substituted at the C-6 position with various groups were designed and synthesized based on the Coenzyme Q10 as potent antioxidant. In vitro antioxidant activities of these compounds were evaluated and compared with commercial antioxidant Coenzyme Q10 employing DPPH assay. All these synthesized Coenzyme Q analogues are found to exhibit good antioxidant activities. Of which Compound 8b bearing a N-benzoylpiperazine group at the C-6 position showed more potent inhibition of DPPH radical than Coenzyme Q10. All these results suggested the applicability of the Coenzyme Q analogues as potent antioxidants for combating oxidative stress.