77716-03-1

Basic information

• Product Name: (1R,5S,9s)-7-benzyl-3-oxa-7-azabicyclo[3.3.1]nonan-9-ol
• CAS NO: 77716-03-1
• Molecular Weight: 233.31
• Mol File: 77716-03-1.mol

Chemical Properties

• CAS DataBase Reference: (1R,5S,9s)-7-benzyl-3-oxa-7-azabicyclo[3.3.1]nonan-9-ol(CAS DataBase Reference)
• NIST Chemistry Reference: (1R,5S,9s)-7-benzyl-3-oxa-7-azabicyclo[3.3.1]nonan-9-ol(77716-03-1)
• EPA Substance Registry System: (1R,5S,9s)-7-benzyl-3-oxa-7-azabicyclo[3.3.1]nonan-9-ol(77716-03-1)

Safety Data

• Hazardous Substances Data: 77716-03-1(Hazardous Substances Data)

Upstream product

• 29943-42-8 Tetrahydro-4H-pyran-4-one 
• 77716-01-9 7-benzyl-3-oxa-7-azabicyclo<3.3.1>nonan-9-one 
• 100-46-9 benzylamine 
• 2182-52-7 benzylamine acetic acid 
• 77716-01-9 7-Benzyl-3-oxa-7-azabicyclo<3.3.1>nonan-9-one 

Downstream Products

• 1147556-26-0 tert-butyl (1R,5S,9r)-9-((6-((2-chloro-4-cyanophenyl)amino)-5-fluoropyrimidin-4-yl)oxy)-3-oxa-7-azabicyclo[3.3.1]nonane-7-carboxylate 
• 934216-26-9 C₂₅H₂₈F₃NO₃ 
• 934182-75-9 C₂₅H₂₈F₃NO₃ 

Relevant articles and documents

Activation of the G-protein-coupled receptor 119: A conformation-base hypothesis for understanding agonist response

The synthesis and properties of the bridged piperidine (oxaazabicyclo) compounds 8, 9, and 11 are described. A conformational analysis of these structures is compared with the representative GPR119 ligand 1. These results and the differences in agonist pharmacology are used to formulate a conformation-based hypothesis to understand activation of the GPR119 receptor. We also show for these structures that the agonist pharmacology in rat masks the important differences in human pharmacology.

Discovery of MK-8282 as a Potent G-Protein-Coupled Receptor 119 Agonist for the Treatment of Type 2 Diabetes

The ever-growing prevalence of type 2 diabetes in the world has necessitated an urgent need for multiple orally effective agents that can regulate glucose homeostasis with a concurrent reduction in body weight. G-Protein coupled receptor 119 (GPR119) is a GPCR target at which agonists have demonstrated glucose-dependent insulin secretion and shows beneficial effects on glycemic control. Herein, we describe our efforts leading to the identification of a potent, oral GPR-119 agonist, MK-8282, which shows improved glucose tolerance in multiple animal models and has excellent off-target profile. The key design elements in the compounds involved a combination of a fluoro-pyrimidine and a conformationally constrained bridged piperidine to impart good potency and efficacy.

CROSS-LINKED CYCLIC AMINE COMPOUNDS AND AGENTS FOR PEST CONTROL

Agents for pest control comprising cyclic amine compounds represented by the formula (1) or salts thereof or N-oxides thereof as an active ingredient, wherein Cy 1 represents an unsubstituted or substituted 5-membered heterocycle or unsubstituted or substituted group represented by the formula (a) below, wherein Y 1 and Y 2 each independently represents nitrogen or carbon and symbol * represents the bonding positions.

INDOLYLPYRIMIDINES AS MODULATORS OF GPR119

The present invention relates to compounds of Formula (I) that are useful for treating, preventing and/or managing the diseases, disorders, syndromes or conditions modulated by GPR119 receptor activity. The invention also relates to the process for preparation of the compounds, pharmaceutical compositions thereof. The invention further relates to methods of treating, preventing and/or managing diseases, disorders syndromes or conditions associated with the modulation of GPR119 receptor by using either alone or in combinations of Formula (I).

BRIDGED CYCLIC AMINE COMPOUND AND PEST CONTROL AGENT

A cyclic amine compound represented by the formula (1): [wherein Cy1 represents an (un)substituted aromatic ring; X represents oxygen, sulfur, (un)substituted nitrogen, sulfinyl, or sulfonyl; R1a and R2a/s

Syntheses and a Conformational Study of Certain Selected 3-Oxa-7-azabicyclononan-9-ones. Single-Crystal X-ray Diffraction Analysis of 6,8-Bis(2-chlorophenyl)-3-oxa-7-azabicyclononan-9-one.

Isomers of 2,4,6,8-tetraphenyl-3-oxa-7-azabicyclononan-9-ones, 6,8-bis(2-chlorophenyl)-3-oxa-7-azabicyclononan-9-one, and N-benzyl-3-oxa-7-azabicyclononan-9-one have been prepared by Mannich-type cyclocondensations with appropiate tet