77728-96-2

Upstream product

• 2274-89-7 5-chloro-4-nito-2,1,3-benzothiadiazole 
• 7440-05-3 palladium 
• 100-46-9 benzylamine 
• 77728-95-1 5-benzylamino-4-nitro-2,1,3-benzothiadiazole 

Downstream Products

• 77728-97-3 5-benzylamino-4-benzylideneamino-2,1,3-benzothiadiazole 
• 77728-89-3 7-phenyl-6-(phenylmethyl)-6H-imidazo<4,5-e>-2,1,3-benzothiadiazole 

Relevant academic research and scientific papers

Benzimidazolone-, benzoxazolone-, or benzothiazolone derivatives as ion channel modulating agents

The present invention relates to ion channel modulating agents. More particularly, the present invention relates to a particular class of chemical compounds that has proven useful as modulators of SKCa, IKCa and BKCa channels. In further aspects, the present invention relates to the use of these SK/IK/BK channel modulating agents for the manufacture of medicaments, and pharmaceutical compositions comprising the SK/IK/BK channel modulating agents. The SK/IK/BK channel modulating agents of the invention are useful for the treatment or alleviation of diseases and conditions associated with the SK/IK/BK channels.

Condensation of 2,1,3-Benzothiadiazole-4,5-diamine with Aromatic Aldehydes

The condensation of 2,1,3-benzothiadiazole-4,5-diamine (I) with aromatic aldehydes yields three types of crystalline products II, III and IV.Compounds II and III have been characterized as isomeric 7-aryl-8 or 6-aralkylimidazobenzothiadiazoles, and IV as