77731-11-4 Usage
General Description
(5beta,7alpha,12alpha)-7,12-Dihydroxychol-3-en-24-oic acid methyl ester, also known as ursodiol, is a bile acid derivative that is used in the treatment of certain liver and gallbladder conditions. It works by reducing the amount of cholesterol produced by the liver and by dissolving gallstones. Ursodiol is also used to prevent gallstones in patients who are undergoing rapid weight loss or have undergone gastric bypass surgery. Additionally, it has been studied for its potential effects on other conditions such as primary biliary cholangitis and nonalcoholic fatty liver disease. Ursodiol is available in both oral and injectable forms and is generally well tolerated with few adverse effects.
Check Digit Verification of cas no
The CAS Registry Mumber 77731-11-4 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 7,7,7,3 and 1 respectively; the second part has 2 digits, 1 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 77731-11:
(7*7)+(6*7)+(5*7)+(4*3)+(3*1)+(2*1)+(1*1)=144
144 % 10 = 4
So 77731-11-4 is a valid CAS Registry Number.
77731-11-4Relevant articles and documents
Potential Bile Acid Metabolites. 8. 7,12-Dihydroxy- and 7β-Hydroxy-5β-cholanic Acids
Iida, Takashi,Chang, Frederic C.
, p. 1194 - 1197 (1983)
Syntheses of 7β-hydroxy- and the stereoisomeric 7,12-dihydroxycholanic acids, their methyl esters, and some related derivatives are described. 12α-Mesyloxy groups, unlike their 7α analogues, were found to be resistant to KO2-crown ether inversion.
A mild one-pot method for conversion of various steroidal secondary alcohols into the corresponding olefins
Kumar, Raju Ranjith,Haveli, Shrutisagar Dattatraya,Kagan, Henri B.
experimental part, p. 1709 - 1712 (2011/09/14)
The addition of Tf2O to some hydroxy steroids in the presence of excess base directly leads to steroidal olefins. This methodology is useful for the one-pot synthesis of Δ2- or Δ3-steroids under mild conditions from the corresponding alcohols. Georg Thieme Verlag Stuttgart · New York.
Olefins of the cholane series from deoxycholic and cholic acids
Brieskorn,Mosandl
, p. 118 - 127 (2007/10/02)
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