77740-81-9

Basic information

• Product Name: 2-Methyl-1-(naphthalen-2-yl)-2-nitropropan-1-ol
• Synonyms: 2-Methyl-1-(naphthalen-2-yl)-2-nitropropan-1-ol
• CAS NO: 77740-81-9
• Molecular Formula: C14H15NO3
• Molecular Weight: 245.2738
• Mol File: 77740-81-9.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2-Methyl-1-(naphthalen-2-yl)-2-nitropropan-1-ol(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Methyl-1-(naphthalen-2-yl)-2-nitropropan-1-ol(77740-81-9)
• EPA Substance Registry System: 2-Methyl-1-(naphthalen-2-yl)-2-nitropropan-1-ol(77740-81-9)

Safety Data

• Hazardous Substances Data: 77740-81-9(Hazardous Substances Data)

Usage

General Description

2-Methyl-1-(naphthalen-2-yl)-2-nitropropan-1-ol is a chemical compound with a molecular formula C13H15NO3. It consists of a naphthalene group attached to a nitropropanol moiety. 2-Methyl-1-(naphthalen-2-yl)-2-nitropropan-1-ol is a nitro alcohol, with a nitro group and an alcohol functional group in its structure. It is commonly used as a building block in organic synthesis, and its derivatives have been studied for various pharmaceutical and industrial applications. The compound exhibits some biological activity and is a potential candidate for further research and development in the field of medicinal chemistry.

Upstream product

• 79-46-9 2-nitropropane 
• 66-99-9 β-naphthaldehyde 
• 18162-48-6 tert-butyldimethylsilyl chloride 

Relevant articles and documents

Calcium receptor antagonist

A compound of the formula [I] wherein R1 is optionally substituted aryl group or optionally substituted heteroaryl group; R2 is optionally substituted C1-6 alkyl group, C3-7 cycloalkyl group and the like; R3 is hydrogen atom, C1-6 alkyl group, hydroxyl group and the like; R4 is hydrogen atom, C1-6 alkyl group and the like; R5 and R6 are each C1-6 alkyl group and the like; R7 is optionally substituted aryl group or optionally substituted heteroaryl group; X1, X2 and X3 are each C1-6 alkylene group and the like; and X4 and X5 are each a single bond, methylene group and the like, a salt thereof, a solvate thereof or a prodrug thereof, and a pharmaceutical composition containing the compound, particularly a calcium receptor antagonist and a therapeutic agent for osteoporosis, are provided. The compound of the present invention is useful as a therapeutic drug of diseases accompanied by abnormal calcium homeostasis, or osteoporosis, hypoparathyreosis, osteosarcoma, periodontal disease, bone fracture, steoarthrosis, chronic rheumatoid arthritis, Paget's disease, humoral hypercalcemia, autosomal dominant hypocalcemia and the like. In addition, an intermediate for the compound is provided.

Preparation of 4-Aryl-1,2,3,4-tetrahydro-3,3-dimethylisoquinolines and 1,2,3,4-Tetrahydro-3,3-dimethyl-4-phenylbenzisoquinolines

Synthetic procedures to prepare a number of 4-aryl-1,2,3,4-tetrahydro-3,3-dimethylisoquinolines and their benzo-homologues 3 through a series of intermediates are described.The condensation of α-(1-amino-1-methylethyl)arylmethanols 5 with arylaldehydes 6