77745-27-8

Basic information

• Product Name: 1-Cyclopentene-1-carboxylicacid,4-amino-(9CI)
• Synonyms: 1-Cyclopentene-1-carboxylicacid,4-amino-(9CI)
• CAS NO: 77745-27-8
• Molecular Formula: C₆H₉NO₂
• Molecular Weight: 127.14116
• Product Categories: AMINOACID
• Mol File: 77745-27-8.mol
• Article Data: 4

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 1-Cyclopentene-1-carboxylicacid,4-amino-(9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Cyclopentene-1-carboxylicacid,4-amino-(9CI)(77745-27-8)
• EPA Substance Registry System: 1-Cyclopentene-1-carboxylicacid,4-amino-(9CI)(77745-27-8)

Safety Data

• Hazardous Substances Data: 77745-27-8(Hazardous Substances Data)

Upstream product

• 1169936-04-2 (±)-methyl 4-(tert-butoxycarbonylamino)cyclopent-1-enecarboxylate 
• 1358799-04-8 (±)-4-(tert-butoxycarbonylamino)cyclopent-1-enecarboxylic acid 
• 49805-30-3 racemic 2-azabicyclo[2.2.1]hept-5-en-3-one 
• 426226-35-9 methyl 4-aminocyclopent-2-ene-1-carboxylate Hydrochloride 
• 1060803-66-8 (+/-)-cis-Methyl-4-tert-butoxycarbonylaminocyclopent-2-en-1-carboxylate 
• 74201-89-1 cis-3-phthalimidocyclopentane-1-carboxylic acid 
• 74201-94-8 methyl 3-(N-benzyloxycarbonylamino)cyclopent-1-ene-1-carboxylate 
• 714195-06-9 methyl 3-aminocyclopentane-1-carboxylate 
• 74201-88-0 3-aminocyclopent-1-ene-1-carboxylic acid 
• 74201-92-6 3-bromocyclopent-1-ene-1-carbonitrile 
• 49805-32-5 cis-3-aminocyclopentane-1-carboxylic acid 
• 3047-38-9 cyclopent-1-enecarbonitrile 
• 99236-92-7 (+/-)-(1β,3β,4β)-4-acetoxy-4-carbamoylcyclopentanedicarboxylic acid 
• 74201-90-4 1-bromo-3-phthalimidocyclopentane-1-carboxylic acid 

Relevant articles and documents

γ-Aminobutyric acid(C) (GABAC) selective antagonists derived from the bioisosteric modification of 4-aminocyclopent-1-enecarboxylic acid: Amides and hydroxamates

Series of compounds were generated via the bioisosteric replacement of the carboxylate of 4-ACPCA (2) with hydroxamate or amide groups. All compounds from this study exhibited increased selectivity for GABAC, the most potent being 4-ACPHA (10a, IC50 = 13 μM) and 4-ACPAM (11a, IC 50 = 10 μM). This provides evidence that a zwitterionic structure is not essential for GABAC antagonists, rather the emphasis lies in appropriate heteroatoms to participate in hydrogen bonding.

Regiospecific synthesis of cyclopentane analogs of (2'- and 3'-deoxy-threo-pentofuranosyl)-uracil and -2-thiouracil nucleosides

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