77746-63-5Relevant academic research and scientific papers
One-Pot Acid-Promoted Synthesis of 6-Aminopyrazolopyrimidines from 1 H-Pyrazol-5-yl- N, N-dimethylformamidines or 5-Amino-1 H-pyrazole-4-carbaldehydes with Cyanamide
Tseng, Ching-Chun,Tsai, Shuo-En,Li, Sin-Min,Wong, Fung Fuh
, p. 16157 - 16170 (2019/12/24)
A convenient and efficient one-pot acid-promoted synthesis of 6-aminopyrazolo[3,4-d]pyrimidine has been developed by treatment of 1H-pyrazol-5-yl-N,N-dimethylformamidines or 5-amino-1H-pyrazole-4-carbaldehydes with cyanamide (NH2CN) in an acid-
Synthesis and antiproliferative evaluation of N,N-disubstituted-N′- [1-aryl-1H-pyrazol-5-yl]-methnimidamides
Cheng, Kaung-Min,Huang, Yu-Ying,Huang, Jiann-Jyh,Kaneko, Kimiyoshi,Kimura, Masayuki,Takayama, Hiroyuki,Juang, Shin-Hun,Wong, Fung Fuh
supporting information; experimental part, p. 6781 - 6784 (2010/12/20)
A series of N,N-disubstituted-N′-[1-aryl-1H-pyrazol-5-yl]- methnimidamides was synthesized by a newly developed microwave reaction and their antiproliferative activities were evaluated. Microwave irradiation of 5-amino-1,3-disubstituted pyrazoles with var
VILSMEIER-HAACK REACTION OF 5-AMINO- AND 5-ACYLAMINO-PYRAZOLES
Simay, A.,Takacs, K.,Horvath, K.,Dvortsak, P.
, p. 127 - 140 (2007/10/02)
The Vilsmeier-Haack reaction of 5-aminopyrazole derivatives 1 was investigated in view of contradictory literature reports.Structure 2 of the products was proved both chemically and spectroscopically.The mechanism of the reaction was postulated on the basis of isolated intermediates 7 and 8. 5-Acylaminopyrazoles 9, 10 and 11 were found to give also 2 (and 7) under the Vilsmeier conditions by an acyl splitting reaction, proceeding probably via diacylamino derivatives 12.Compounds 2 provided a simple route to pyrazolopyrimidine derivatives 13 and 14 as well as to azomethine compounds 15-18.
