77747-76-3Relevant articles and documents
Synthesis of isomeric isoxazolopyridinones
Weis, Robert,Schweiger, Klaus,Fabian, Walter M. F.
, p. 1285 - 1292 (1998)
Reaction of 4-methylamino-5,6-dihydropyridinone with acetyl chloride yielded exclusively the 3-acetyl derivative. When the methylamino group of the latter was removed by alkaline hydrolysis, a mixture of two hydroxy derivatives was formed. Those cyclized upon treatment with hydroxylamine exclusively to the isoxazolo[4,5-c]pyridinone, whereas the 4-methylamino analogue yielded, depending on pH, mainly the isoxazolo[4,3-c]pyridinone or the isoxazolo[4,5-c]pyridinone. The configurations of the latter compounds were established by NMR experiments.