7776-05-8Relevant academic research and scientific papers
CYP267A1 and CYP267B1 from sorangium cellulosum so ce56 are highly versatile drug metabolizers
Kern, Fredy,Khatri, Yogan,Litzenburger, Martin,Bernhardt, Rita
, p. 495 - 504 (2016/04/05)
The guidelines of the Food and Drug Administration and International Conference on Harmonization have highlighted the importance of drug metabolites in clinical trials. As a result, an authentic source for their production is of great interest, both for t
Facile syntheses of the three major metabolites of thioridazine
Morrow, Ryan J.,Millership, Jeff S.,Collier, Paul S.
, p. 962 - 967 (2007/10/03)
Efficient, mild syntheses of the three major metabolites 2-4 of the important antipsychotic drug thioridazine (1) have been developed. The cardiotoxic metabolite 2 with a ring sulfoxide moiety was prepared in 96% yield by oxidation of 1 with NaIO4 under acidic conditions. Four different procedures were elaborated for the selective side-chain sulfide oxidation of 1 to mesoridazine (3), giving rise to yields of up to 91%. Finally, sulforidazine (4) was synthesised via oxidation of the sulfoxide 3 in the presence of either KMnO4 or t-BuOOH under basic conditions. Except for the oxidation with t-BuOOH. all reactions took place under mild conditions within a few minutes, were nicely reproducible, and afforded medium-to-high yields of the desired products, which could be readily purified by column chromatography.
Analytical studies and application of reaction of promazine and thioridazine hydrochlorides with some oxidants
Puzanowska-Tarasiewicz, Helena,Karpinska, Joanna
, p. 409 - 415 (2007/10/03)
The run and analytical application of oxidation reaction of promazine (PM) and thioridazine (TR) hydrochlorides with iron(III) and ferrocyanide(III) are described. The coloured products of oxidation absorb at 512 nm for promazine and 634 nm for thioridazine. This property is a basis of a rapid, accurate and sensitive spectrophotometric method for determination of these phenothiazines. The elaborated methods allow to determine 3-28 μgPM/ml in Fe(III)-PM and 2-11 μgPM/ml in [Fe(CN)6]3 - PM systems, 2.5-22 μgTR/ml in the Fe(III)-TR and 4-16 μgTR/ml in [Fe(CN)6]3- - TR systems.
